BAIT
SH3GL2
CNSA2, EEN-B1, SH3D2A, SH3P4
SH3-domain GRB2-like 2
GO Process (9)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- axon guidance [TAS]
- central nervous system development [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- membrane organization [TAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- post-Golgi vesicle-mediated transport [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GCH1
DYT14, DYT5, DYT5a, GCH, GTP-CH-1, GTPCH1, HPABH4B
GTP cyclohydrolase 1
GO Process (17)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
- GTP catabolic process [IDA]
- dopamine biosynthetic process [IDA]
- metabolic process [IDA]
- neuromuscular process controlling posture [IMP]
- nitric oxide biosynthetic process [NAS]
- nitric oxide metabolic process [TAS]
- positive regulation of nitric-oxide synthase activity [IDA, IMP]
- protein homooligomerization [IDA]
- pteridine-containing compound biosynthetic process [IDA]
- regulation of blood pressure [IMP]
- regulation of nitric-oxide synthase activity [TAS]
- response to interferon-gamma [IDA]
- response to lipopolysaccharide [IDA, IEP]
- response to pain [ISS]
- response to tumor necrosis factor [IDA]
- small molecule metabolic process [TAS]
- tetrahydrobiopterin biosynthetic process [IDA, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A directed protein interaction network for investigating intracellular signal transduction.
Cellular signal transduction is a complex process involving protein-protein interactions (PPIs) that transmit information. For example, signals from the plasma membrane may be transduced to transcription factors to regulate gene expression. To obtain a global view of cellular signaling and to predict potential signal modulators, we searched for protein interaction partners of more than 450 signaling-related proteins by means of ... [more]
Sci Signal Sep. 06, 2011; 4(189);rs8 [Pubmed: 21900206]
Throughput
- High Throughput
Curated By
- BioGRID