BAIT
RELA
NFKB3, p65
v-rel avian reticuloendotheliosis viral oncogene homolog A
GO Process (43)
GO Function (20)
GO Component (5)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- T cell receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- cellular defense response [NAS]
- cellular response to hydrogen peroxide [IDA]
- cellular response to interleukin-1 [IDA]
- cellular response to interleukin-6 [IMP]
- cellular response to nicotine [IMP]
- cellular response to peptide hormone stimulus [IMP]
- cellular response to tumor necrosis factor [IDA]
- cytokine-mediated signaling pathway [IDA]
- defense response to virus [NAS]
- inflammatory response [IDA]
- innate immune response [TAS]
- membrane protein intracellular domain proteolysis [TAS]
- negative regulation of apoptotic process [IDA, TAS]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- nucleotide-binding oligomerization domain containing 2 signaling pathway [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IEP]
- positive regulation of NF-kappaB transcription factor activity [IDA, TAS]
- positive regulation of cell proliferation [IDA]
- positive regulation of miRNA metabolic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of type I interferon production [TAS]
- regulation of inflammatory response [ISS]
- response to UV-B [IDA]
- response to interleukin-1 [IGI]
- response to organic substance [IDA]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function- DNA binding [IDA]
- NF-kappaB binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- activating transcription factor binding [IPI]
- chromatin binding [IDA]
- identical protein binding [IDA, IPI]
- phosphate ion binding [IDA]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- ubiquitin protein ligase binding [IPI]
- DNA binding [IDA]
- NF-kappaB binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- activating transcription factor binding [IPI]
- chromatin binding [IDA]
- identical protein binding [IDA, IPI]
- phosphate ion binding [IDA]
- protein N-terminus binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- ubiquitin protein ligase binding [IPI]
Homo sapiens
PREY
MAPK14
CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA, RP1-179N16.5
mitogen-activated protein kinase 14
GO Process (46)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- 3'-UTR-mediated mRNA stabilization [TAS]
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- RNA metabolic process [TAS]
- Ras protein signal transduction [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of MAPK activity [TAS]
- blood coagulation [TAS]
- cell surface receptor signaling pathway [TAS]
- cellular component movement [TAS]
- cellular response to ionizing radiation [IMP]
- cellular response to lipopolysaccharide [IDA]
- cellular response to vascular endothelial growth factor stimulus [IMP]
- chemotaxis [TAS]
- gene expression [TAS]
- innate immune response [TAS]
- intracellular signal transduction [IDA]
- mRNA metabolic process [TAS]
- muscle cell differentiation [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- osteoclast differentiation [ISS]
- p38MAPK cascade [ISS]
- peptidyl-serine phosphorylation [ISS]
- platelet activation [TAS]
- positive regulation of blood vessel endothelial cell migration [IMP]
- positive regulation of muscle cell differentiation [TAS]
- positive regulation of myoblast differentiation [ISS]
- positive regulation of myoblast fusion [ISS]
- positive regulation of myotube differentiation [ISS]
- positive regulation of reactive oxygen species metabolic process [IMP]
- regulation of sequence-specific DNA binding transcription factor activity [TAS]
- regulation of transcription from RNA polymerase II promoter [ISS]
- signal transduction [TAS]
- signal transduction in response to DNA damage [IMP]
- stress-activated MAPK cascade [TAS]
- stress-induced premature senescence [IMP]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
- vascular endothelial growth factor receptor signaling pathway [IMP]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A directed protein interaction network for investigating intracellular signal transduction.
Cellular signal transduction is a complex process involving protein-protein interactions (PPIs) that transmit information. For example, signals from the plasma membrane may be transduced to transcription factors to regulate gene expression. To obtain a global view of cellular signaling and to predict potential signal modulators, we searched for protein interaction partners of more than 450 signaling-related proteins by means of ... [more]
Sci Signal Sep. 06, 2011; 4(189);rs8 [Pubmed: 21900206]
Throughput
- High Throughput
Curated By
- BioGRID