BAIT
RPS6KA5
MSK1, MSPK1, RLPK
ribosomal protein S6 kinase, 90kDa, polypeptide 5
GO Process (32)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- axon guidance [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- histone H2A-S1 phosphorylation [IDA]
- histone H3-S10 phosphorylation [IMP]
- histone H3-S28 phosphorylation [IMP]
- histone phosphorylation [IDA, TAS]
- innate immune response [TAS]
- interleukin-1-mediated signaling pathway [IMP]
- intracellular signal transduction [IDA]
- negative regulation of cytokine production [TAS]
- negative regulation of transcription, DNA-templated [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of CREB transcription factor activity [TAS]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of histone acetylation [IMP]
- positive regulation of histone phosphorylation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein phosphorylation [IDA]
- regulation of transcription, DNA-templated [IDA, IMP]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
SMAD6
AOVD2, HsT17432, MADH6, MADH7
SMAD family member 6
GO Process (13)
GO Function (12)
GO Component (4)
Gene Ontology Biological Process
- BMP signaling pathway [IDA, TAS]
- cell-substrate adhesion [IMP]
- fat cell differentiation [IDA]
- immune response [IMP]
- intracellular signal transduction [IDA, IMP]
- negative regulation of BMP signaling pathway [IDA]
- negative regulation of SMAD protein complex assembly [IDA]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of pathway-restricted SMAD protein phosphorylation [IDA, IMP]
- negative regulation of transforming growth factor beta receptor signaling pathway [IMP]
- response to laminar fluid shear stress [IEP]
- zygotic specification of dorsal/ventral axis [IMP]
Gene Ontology Molecular Function- I-SMAD binding [IPI]
- R-SMAD binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- chromatin binding [IDA]
- co-SMAD binding [IPI]
- identical protein binding [IPI]
- protein binding [IPI]
- transcription regulatory region DNA binding [IDA]
- transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity [IDA, IMP]
- type I activin receptor binding [IDA]
- type I transforming growth factor beta receptor binding [IDA]
- ubiquitin protein ligase binding [IPI]
- I-SMAD binding [IPI]
- R-SMAD binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- chromatin binding [IDA]
- co-SMAD binding [IPI]
- identical protein binding [IPI]
- protein binding [IPI]
- transcription regulatory region DNA binding [IDA]
- transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity [IDA, IMP]
- type I activin receptor binding [IDA]
- type I transforming growth factor beta receptor binding [IDA]
- ubiquitin protein ligase binding [IPI]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A directed protein interaction network for investigating intracellular signal transduction.
Cellular signal transduction is a complex process involving protein-protein interactions (PPIs) that transmit information. For example, signals from the plasma membrane may be transduced to transcription factors to regulate gene expression. To obtain a global view of cellular signaling and to predict potential signal modulators, we searched for protein interaction partners of more than 450 signaling-related proteins by means of ... [more]
Sci Signal Sep. 06, 2011; 4(189);rs8 [Pubmed: 21900206]
Throughput
- High Throughput
Curated By
- BioGRID