BAIT
TNFSF11
CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf, RP11-86N24.2
tumor necrosis factor (ligand) superfamily, member 11
GO Process (18)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- TNFSF11-mediated signaling pathway [IDA]
- cytokine-mediated signaling pathway [IDA]
- immune response [NAS]
- monocyte chemotaxis [IDA]
- osteoclast differentiation [IDA, ISS, NAS]
- positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling [IDA]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of T cell activation [IDA]
- positive regulation of bone resorption [IDA]
- positive regulation of corticotropin-releasing hormone secretion [ISS]
- positive regulation of fever generation by positive regulation of prostaglandin secretion [ISS]
- positive regulation of homotypic cell-cell adhesion [IDA]
- positive regulation of intracellular signal transduction [IDA]
- positive regulation of osteoclast differentiation [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- tumor necrosis factor-mediated signaling pathway [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
EEF1A1
CCS-3, CCS3, EE1A1, EEF-1, EEF1A, EF-Tu, EF1A, GRAF-1EF, HNGC:16303, LENG7, PTI1, eEF1A-1, RP11-505P4.2
eukaryotic translation elongation factor 1 alpha 1
GO Process (5)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A directed protein interaction network for investigating intracellular signal transduction.
Cellular signal transduction is a complex process involving protein-protein interactions (PPIs) that transmit information. For example, signals from the plasma membrane may be transduced to transcription factors to regulate gene expression. To obtain a global view of cellular signaling and to predict potential signal modulators, we searched for protein interaction partners of more than 450 signaling-related proteins by means of ... [more]
Sci Signal Sep. 06, 2011; 4(189);rs8 [Pubmed: 21900206]
Throughput
- High Throughput
Curated By
- BioGRID