TK1
Gene Ontology Biological Process
- deoxyribonucleoside monophosphate biosynthetic process [TAS]
- nucleobase-containing compound metabolic process [TAS]
- nucleobase-containing small molecule metabolic process [TAS]
- nucleotide biosynthetic process [EXP]
- protein homotetramerization [IPI]
- pyrimidine nucleobase metabolic process [TAS]
- pyrimidine nucleoside salvage [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
TYK2
Gene Ontology Biological Process
- cell differentiation [IBA]
- cell migration [IBA]
- cytokine-mediated signaling pathway [TAS]
- innate immune response [IBA]
- peptidyl-tyrosine autophosphorylation [IBA]
- protein phosphorylation [TAS]
- regulation of cell proliferation [IBA]
- regulation of type I interferon-mediated signaling pathway [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A directed protein interaction network for investigating intracellular signal transduction.
Cellular signal transduction is a complex process involving protein-protein interactions (PPIs) that transmit information. For example, signals from the plasma membrane may be transduced to transcription factors to regulate gene expression. To obtain a global view of cellular signaling and to predict potential signal modulators, we searched for protein interaction partners of more than 450 signaling-related proteins by means of ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TK1 TYK2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -2.789 | BioGRID | 2538256 |
Curated By
- BioGRID