BAIT
PTK2
FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK
protein tyrosine kinase 2
GO Process (42)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- angiogenesis [IBA, TAS]
- apoptotic process [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell motility [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cytoskeleton organization [IBA]
- embryo development [TAS]
- ephrin receptor signaling pathway [IDA]
- epidermal growth factor receptor signaling pathway [IBA]
- establishment of cell polarity [TAS]
- growth hormone receptor signaling pathway [IDA]
- heart morphogenesis [TAS]
- innate immune response [IBA, TAS]
- integrin-mediated signaling pathway [IDA, IMP, TAS]
- negative regulation of anoikis [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell-cell adhesion [IDA]
- netrin-activated signaling pathway [TAS]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA]
- placenta development [TAS]
- platelet activation [TAS]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [ISS]
- positive regulation of phosphatidylinositol 3-kinase activity [TAS]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of protein kinase B signaling [IMP]
- positive regulation of protein kinase activity [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISS]
- protein autophosphorylation [IDA]
- regulation of Rho GTPase activity [TAS]
- regulation of cell adhesion mediated by integrin [IDA]
- regulation of cell proliferation [IMP]
- regulation of cell shape [IMP]
- regulation of cytoskeleton organization [TAS]
- regulation of endothelial cell migration [TAS]
- regulation of focal adhesion assembly [TAS]
- regulation of osteoblast differentiation [IMP]
- transforming growth factor beta receptor signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ZNF331
RITA, ZNF361, ZNF463
zinc finger protein 331
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A directed protein interaction network for investigating intracellular signal transduction.
Cellular signal transduction is a complex process involving protein-protein interactions (PPIs) that transmit information. For example, signals from the plasma membrane may be transduced to transcription factors to regulate gene expression. To obtain a global view of cellular signaling and to predict potential signal modulators, we searched for protein interaction partners of more than 450 signaling-related proteins by means of ... [more]
Sci Signal Sep. 06, 2011; 4(189);rs8 [Pubmed: 21900206]
Throughput
- High Throughput
Curated By
- BioGRID