BAIT
MAPK6
ERK3, HsT17250, PRKM6, p97MAPK
mitogen-activated protein kinase 6
GO Process (3)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
CDH13
CDHH, P105
cadherin 13
GO Process (24)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- Rac protein signal transduction [IMP]
- Rho protein signal transduction [IMP]
- adherens junction organization [TAS]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [IDA]
- cell junction assembly [TAS]
- cell-cell junction organization [TAS]
- endothelial cell migration [IDA]
- homophilic cell adhesion via plasma membrane adhesion molecules [IDA]
- keratinocyte proliferation [IDA]
- lamellipodium assembly [IDA]
- localization within membrane [IMP]
- low-density lipoprotein particle mediated signaling [IDA]
- negative regulation of cell adhesion [IDA]
- negative regulation of cell proliferation [IDA]
- positive regulation of calcium-mediated signaling [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell-matrix adhesion [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of positive chemotaxis [IDA]
- positive regulation of smooth muscle cell proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of endocytosis [IMP]
- regulation of epidermal growth factor receptor signaling pathway [IMP]
- sprouting angiogenesis [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A directed protein interaction network for investigating intracellular signal transduction.
Cellular signal transduction is a complex process involving protein-protein interactions (PPIs) that transmit information. For example, signals from the plasma membrane may be transduced to transcription factors to regulate gene expression. To obtain a global view of cellular signaling and to predict potential signal modulators, we searched for protein interaction partners of more than 450 signaling-related proteins by means of ... [more]
Sci Signal Sep. 06, 2011; 4(189);rs8 [Pubmed: 21900206]
Throughput
- High Throughput
Curated By
- BioGRID