BioGRID COVID-19 Coronavirus Curation Project
Search BioGRID for SARS-CoV-2 Protein Interactions | Download SARS-CoV-2 and Coronavirus-Related Interactions

BAIT

TNNT1

ANM, NEM5, STNT, TNT, TNTS

troponin T type 1 (skeletal, slow)

GO Process (3)

GO Function (1)

GO Component (2)

Gene Ontology Biological Process

muscle filament sliding [TAS]

negative regulation of muscle contraction [IDA]

skeletal muscle contraction [IMP]

Gene Ontology Molecular Function

tropomyosin binding [IMP]

Gene Ontology Cellular Component

troponin complex [IDA, IMP]

CRISPR Database VEGA HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

FYN

SLK, SYN, p59-FYN, RP1-66H14.1

FYN proto-oncogene, Src family tyrosine kinase

Alzheimer's Disease Project

GO Process (29)

GO Function (6)

GO Component (5)

Gene Ontology Biological Process

Fc-epsilon receptor signaling pathway [TAS]

Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]

T cell activation [IBA]

T cell costimulation [TAS]

T cell receptor signaling pathway [IDA]

axon guidance [TAS]

blood coagulation [TAS]

calcium ion transport [NAS]

cell differentiation [IBA]

cell migration [IBA]

cellular response to peptide hormone stimulus [IBA]

central nervous system development [IBA]

epidermal growth factor receptor signaling pathway [TAS]

feeding behavior [TAS]

fibroblast growth factor receptor signaling pathway [TAS]

innate immune response [IBA, TAS]

intracellular signal transduction [TAS]

leukocyte migration [TAS]

neurotrophin TRK receptor signaling pathway [TAS]

peptidyl-tyrosine autophosphorylation [IBA]

phosphatidylinositol-mediated signaling [TAS]

platelet activation [TAS]

protein phosphorylation [NAS]

regulation of apoptotic process [IBA]

regulation of cell proliferation [IBA]

regulation of defense response to virus by virus [TAS]

transmembrane receptor protein tyrosine kinase signaling pathway [IBA]

viral process [TAS]

Gene Ontology Molecular Function

ephrin receptor binding [IPI]
glycoprotein binding [IPI]
growth factor receptor binding [IPI]
non-membrane spanning protein tyrosine kinase activity [NAS]
protein binding [IPI]
protein tyrosine kinase activity [EXP, TAS]

Gene Ontology Cellular Component

extrinsic component of cytoplasmic side of plasma membrane [IBA]

membrane raft [IDA]

plasma membrane [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

A directed protein interaction network for investigating intracellular signal transduction.

Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA, Wanker EE

Cellular signal transduction is a complex process involving protein-protein interactions (PPIs) that transmit information. For example, signals from the plasma membrane may be transduced to transcription factors to regulate gene expression. To obtain a global view of cellular signaling and to predict potential signal modulators, we searched for protein interaction partners of more than 450 signaling-related proteins by means of ... [more]

Sci Signal Sep. 06, 2011; 4(189);rs8 [Pubmed: 21900206]

Throughput

High Throughput

Curated By

BioGRID