BAIT
RGS2
G0S8, GIG31
regulator of G-protein signaling 2
GO Process (8)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- negative regulation of G-protein coupled receptor protein signaling pathway [ISS]
- negative regulation of MAP kinase activity [ISS]
- negative regulation of cardiac muscle hypertrophy [ISS]
- negative regulation of phospholipase activity [ISS]
- positive regulation of cardiac muscle contraction [ISS]
- regulation of G-protein coupled receptor protein signaling pathway [TAS]
- regulation of adrenergic receptor signaling pathway [ISS]
- relaxation of cardiac muscle [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
LIG1
ligase I, DNA, ATP-dependent
GO Process (16)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- DNA metabolic process [TAS]
- DNA repair [TAS]
- DNA strand elongation involved in DNA replication [TAS]
- V(D)J recombination [IDA]
- anatomical structure morphogenesis [TAS]
- base-excision repair [TAS]
- double-strand break repair [TAS]
- double-strand break repair via homologous recombination [TAS]
- lagging strand elongation [IBA]
- mitotic cell cycle [TAS]
- nucleotide-excision repair [IBA, TAS]
- nucleotide-excision repair, DNA gap filling [TAS]
- telomere maintenance [TAS]
- telomere maintenance via recombination [TAS]
- telomere maintenance via semi-conservative replication [TAS]
- transcription-coupled nucleotide-excision repair [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A directed protein interaction network for investigating intracellular signal transduction.
Cellular signal transduction is a complex process involving protein-protein interactions (PPIs) that transmit information. For example, signals from the plasma membrane may be transduced to transcription factors to regulate gene expression. To obtain a global view of cellular signaling and to predict potential signal modulators, we searched for protein interaction partners of more than 450 signaling-related proteins by means of ... [more]
Sci Signal Sep. 06, 2011; 4(189);rs8 [Pubmed: 21900206]
Throughput
- High Throughput
Curated By
- BioGRID