BAIT
ARHGEF6
COOL2, Cool-2, MRX46, PIXA, alpha-PIX, alphaPIX, RP3-527F8.4
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
GO Process (11)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- JNK cascade [NAS]
- apoptotic process [NAS]
- apoptotic signaling pathway [TAS]
- cell junction assembly [TAS]
- lamellipodium assembly [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of GTPase activity [NAS]
- positive regulation of Rho GTPase activity [NAS]
- positive regulation of apoptotic process [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
GPRASP2
GASP2, RP4-769N13.4
G protein-coupled receptor associated sorting protein 2
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A directed protein interaction network for investigating intracellular signal transduction.
Cellular signal transduction is a complex process involving protein-protein interactions (PPIs) that transmit information. For example, signals from the plasma membrane may be transduced to transcription factors to regulate gene expression. To obtain a global view of cellular signaling and to predict potential signal modulators, we searched for protein interaction partners of more than 450 signaling-related proteins by means of ... [more]
Sci Signal Sep. 06, 2011; 4(189);rs8 [Pubmed: 21900206]
Throughput
- High Throughput
Curated By
- BioGRID