BAIT
WT1
AWT1, EWS-WT1, GUD, NPHS4, WAGR, WIT-2, WT33
Wilms tumor 1
GO Process (47)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- RNA splicing [ISS]
- adrenal cortex formation [ISS]
- adrenal gland development [IGI]
- branching involved in ureteric bud morphogenesis [IGI]
- camera-type eye development [ISS]
- cardiac muscle cell fate commitment [ISS]
- cellular response to cAMP [IEP]
- cellular response to gonadotropin stimulus [IDA]
- diaphragm development [ISS]
- epithelial cell differentiation [ISS]
- germ cell development [ISS]
- glomerular basement membrane development [IMP]
- glomerular visceral epithelial cell differentiation [IBA, ISS]
- glomerulus development [IGI]
- gonad development [ISS]
- heart development [IGI]
- kidney development [IGI]
- male genitalia development [ISS]
- male gonad development [IEP]
- mesenchymal to epithelial transition [ISS]
- metanephric S-shaped body morphogenesis [IGI]
- metanephric epithelium development [IEP]
- metanephric mesenchyme development [ISS]
- negative regulation of apoptotic process [IGI]
- negative regulation of cell growth [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of female gonad development [ISS]
- negative regulation of metanephric glomerular mesangial cell proliferation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of translation [IDA]
- positive regulation of apoptotic process [IDA]
- positive regulation of heart growth [ISS]
- positive regulation of male gonad development [ISS]
- positive regulation of metanephric ureteric bud development [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of transcription, DNA-templated [IDA, IGI]
- posterior mesonephric tubule development [ISS]
- regulation of organ formation [ISS]
- regulation of transcription from RNA polymerase II promoter [ISS]
- regulation of transcription, DNA-templated [ISS, NAS]
- sex determination [IDA]
- thorax and anterior abdomen determination [ISS]
- tissue development [ISS]
- ureteric bud development [ISS]
- vasculogenesis [ISS]
- visceral serous pericardium development [IGI]
Gene Ontology Molecular Function- C2H2 zinc finger domain binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISS]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [ISS, NAS]
- transcription regulatory region DNA binding [IDA]
- zinc ion binding [IDA]
- C2H2 zinc finger domain binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISS]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [ISS, NAS]
- transcription regulatory region DNA binding [IDA]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
- cytoplasm [IBA, ISS]
- nuclear speck [IDA]
- nucleoplasm [IDA]
- nucleus [IDA]
Homo sapiens
PREY
TAOK1
KFC-B, MAP3K16, MARKK, PSK-2, PSK2, TAO1, hKFC-B, hTAOK1
TAO kinase 1
GO Process (11)
GO Function (7)
GO Component (2)
Gene Ontology Biological Process
- G2 DNA damage checkpoint [IMP]
- MAPK cascade [IBA]
- activation of MAPKK activity [IBA]
- cellular response to DNA damage stimulus [IDA]
- execution phase of apoptosis [IDA]
- mitotic cell cycle [TAS]
- positive regulation of JNK cascade [IDA]
- positive regulation of stress-activated MAPK cascade [IMP]
- protein phosphorylation [NAS]
- regulation of cytoskeleton organization [ISS]
- spindle checkpoint [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A directed protein interaction network for investigating intracellular signal transduction.
Cellular signal transduction is a complex process involving protein-protein interactions (PPIs) that transmit information. For example, signals from the plasma membrane may be transduced to transcription factors to regulate gene expression. To obtain a global view of cellular signaling and to predict potential signal modulators, we searched for protein interaction partners of more than 450 signaling-related proteins by means of ... [more]
Sci Signal Sep. 06, 2011; 4(189);rs8 [Pubmed: 21900206]
Throughput
- High Throughput
Curated By
- BioGRID