BAIT
ITGB1BP1
ICAP-1A, ICAP-1B, ICAP-1alpha, ICAP1, ICAP1A, ICAP1B
integrin beta 1 binding protein 1
GO Process (34)
GO Function (5)
GO Component (12)
Gene Ontology Biological Process
- activation of protein kinase B activity [IDA]
- blood vessel endothelial cell proliferation involved in sprouting angiogenesis [IDA]
- cell migration [TAS]
- cell-matrix adhesion [IDA]
- cellular response to fibroblast growth factor stimulus [IDA]
- cellular response to vascular endothelial growth factor stimulus [IDA]
- integrin activation [ISS]
- integrin-mediated signaling pathway [IDA]
- intracellular signal transduction [TAS]
- myoblast migration [ISS]
- negative regulation of ERK1 and ERK2 cascade [IDA]
- negative regulation of cell adhesion involved in substrate-bound cell migration [ISS]
- negative regulation of cell migration involved in sprouting angiogenesis [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of fibroblast migration [ISS]
- negative regulation of focal adhesion assembly [IDA]
- negative regulation of protein binding [IDA]
- negative regulation of protein kinase activity [IDA]
- negative regulation of protein targeting to membrane [IDA]
- negative regulation of substrate adhesion-dependent cell spreading [IDA]
- positive regulation of Notch signaling pathway [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of protein targeting to membrane [ISS]
- positive regulation of stress fiber assembly [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein transport [IDA]
- receptor clustering [ISS]
- regulation of Cdc42 GTPase activity [IDA]
- regulation of blood vessel size [IDA]
- regulation of cell adhesion mediated by integrin [ISS]
- regulation of integrin-mediated signaling pathway [ISS]
- tube formation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
EEF1A1
CCS-3, CCS3, EE1A1, EEF-1, EEF1A, EF-Tu, EF1A, GRAF-1EF, HNGC:16303, LENG7, PTI1, eEF1A-1, RP11-505P4.2
eukaryotic translation elongation factor 1 alpha 1
GO Process (5)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A directed protein interaction network for investigating intracellular signal transduction.
Cellular signal transduction is a complex process involving protein-protein interactions (PPIs) that transmit information. For example, signals from the plasma membrane may be transduced to transcription factors to regulate gene expression. To obtain a global view of cellular signaling and to predict potential signal modulators, we searched for protein interaction partners of more than 450 signaling-related proteins by means of ... [more]
Sci Signal Sep. 06, 2011; 4(189);rs8 [Pubmed: 21900206]
Throughput
- High Throughput
Curated By
- BioGRID