A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Brr6 drives the Schizosaccharomyces pombe spindle pole body nuclear envelope insertion/extrusion cycle.

Tamm T, Grallert A, Grossman EP, Alvarez-Tabares I, Stevens FE, Hagan IM

The fission yeast interphase spindle pole body (SPB) is a bipartite structure in which a bulky cytoplasmic domain is separated from a nuclear component by the nuclear envelope. During mitosis, the SPB is incorporated into a fenestra that forms within the envelope during mitotic commitment. Closure of this fenestra during anaphase B/mitotic exit returns the cytoplasmic component to the cytoplasmic ... [more]

J. Cell Biol. Oct. 31, 2011; 195(3);467-84 [Pubmed: 22042620]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)
phenotype: heat sensitivity (APO:0000147)

Additional Notes

brr6.ts8 kms2 double mutant is synthetic lethal at 32 degrees

Curated By

BioGRID

Interaction Summary

BRR6

Gene Ontology Biological Process

Gene Ontology Cellular Component

KMS2