BAIT

APQ12

SPBC428.04
nuclear membrane organization protein Apq12 (predicted)
GO Process (2)
GO Function (0)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)
PREY

CUT12

stf1, SPBC649.05
spindle pole body protein Cut12
GO Process (2)
GO Function (1)
GO Component (4)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Brr6 drives the Schizosaccharomyces pombe spindle pole body nuclear envelope insertion/extrusion cycle.

Tamm T, Grallert A, Grossman EP, Alvarez-Tabares I, Stevens FE, Hagan IM

The fission yeast interphase spindle pole body (SPB) is a bipartite structure in which a bulky cytoplasmic domain is separated from a nuclear component by the nuclear envelope. During mitosis, the SPB is incorporated into a fenestra that forms within the envelope during mitotic commitment. Closure of this fenestra during anaphase B/mitotic exit returns the cytoplasmic component to the cytoplasmic ... [more]

J. Cell Biol. Oct. 31, 2011; 195(3);467-84 [Pubmed: 22042620]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)
  • phenotype: cold sensitivity (APO:0000148)

Additional Notes

  • apq12 cut12.1 double mutant is synthetic lethal at 20 degrees

Curated By

  • BioGRID