BAIT
APQ12
SPBC428.04
nuclear membrane organization protein Apq12 (predicted)
GO Process (2)
GO Function (0)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
SAD1
SPBC16H5.01c, SPBC12D12.01
spindle pole body protein Sad1
GO Process (2)
GO Function (1)
GO Component (9)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- SUN-KASH complex [IPI]
- condensed nuclear chromosome, centromeric region [IDA]
- integral component of nuclear inner membrane [TAS]
- interphase microtubule organizing center [IDA]
- meiotic spindle pole body [IDA]
- mitotic spindle pole body [IDA]
- nuclear chromosome, telomeric region [IDA]
- nuclear envelope [IDA]
- site of double-strand break [IDA]
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Brr6 drives the Schizosaccharomyces pombe spindle pole body nuclear envelope insertion/extrusion cycle.
The fission yeast interphase spindle pole body (SPB) is a bipartite structure in which a bulky cytoplasmic domain is separated from a nuclear component by the nuclear envelope. During mitosis, the SPB is incorporated into a fenestra that forms within the envelope during mitotic commitment. Closure of this fenestra during anaphase B/mitotic exit returns the cytoplasmic component to the cytoplasmic ... [more]
J. Cell Biol. Oct. 31, 2011; 195(3);467-84 [Pubmed: 22042620]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
- phenotype: cold sensitivity (APO:0000148)
Additional Notes
- apq12 sad1.2 double mutant is synthetic lethal at 30 degrees
Curated By
- BioGRID