BAIT
NRGN
RC3, hng
neurogranin (protein kinase C substrate, RC3)
GO Process (2)
GO Function (0)
GO Component (0)
Gene Ontology Biological Process
Homo sapiens
PREY
CALM1
AI256814, AI327027, AI461935, AL024000, CaM, Calm
calmodulin 1
GO Process (3)
GO Function (11)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function- adenylate cyclase binding [ISO]
- calcium ion binding [ISO, TAS]
- calcium-dependent protein binding [ISO]
- enzyme regulator activity [ISO]
- ion channel binding [ISO]
- nitric-oxide synthase binding [ISO]
- nitric-oxide synthase regulator activity [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein N-terminus binding [ISO]
- protein domain specific binding [ISO]
- type 3 metabotropic glutamate receptor binding [ISO]
- adenylate cyclase binding [ISO]
- calcium ion binding [ISO, TAS]
- calcium-dependent protein binding [ISO]
- enzyme regulator activity [ISO]
- ion channel binding [ISO]
- nitric-oxide synthase binding [ISO]
- nitric-oxide synthase regulator activity [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein N-terminus binding [ISO]
- protein domain specific binding [ISO]
- type 3 metabotropic glutamate receptor binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Interactions between neurogranin and calmodulin in vivo.
Neurogranin is a neural-specific, calmodulin (CaM)-binding protein that is phosphorylated by protein kinase C (PKC) within its IQ domain at serine 36. Since CaM binds to neurogranin through the IQ domain, PKC phosphorylation and CaM binding are mutually exclusive. Consequently, we hypothesize that neurogranin may function to concentrate CaM at specific sites in neurons and release free CaM in response ... [more]
J. Biol. Chem. Mar. 19, 1999; 274(12);7689-94 [Pubmed: 10075657]
Throughput
- Low Throughput
Curated By
- BioGRID