NEURL1A
Gene Ontology Biological Process
- cellular response to amino acid stimulus [IDA]
- lactation [IMP]
- negative regulation of Notch signaling pathway [ISO]
- negative regulation of cell proliferation [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of dendritic spine development [IDA]
- positive regulation of epidermal growth factor-activated receptor activity [IMP]
- positive regulation of filopodium assembly [IDA]
- positive regulation of long-term neuronal synaptic plasticity [IDA]
- positive regulation of synapse maturation [IDA]
- protein monoubiquitination [IDA]
- regulation of translation [IDA]
- sperm axoneme assembly [IMP]
- sperm motility [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CPEB3
Gene Ontology Biological Process
- 3'-UTR-mediated mRNA destabilization [ISO]
- cellular response to amino acid stimulus [IDA, ISO]
- long-term memory [IMP]
- negative regulation of cytoplasmic translational elongation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of translation [IDA, IMP, ISO]
- positive regulation of dendritic spine development [IDA]
- positive regulation of mRNA polyadenylation [IDA]
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [ISO]
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [ISO]
- positive regulation of translation [IDA]
- regulation of dendritic spine development [IMP]
- regulation of synaptic plasticity [IMP]
- translation [IDA, ISO]
Gene Ontology Molecular Function
Biochemical Activity (Ubiquitination)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Neuralized1 Activates CPEB3: A Function for Nonproteolytic Ubiquitin in Synaptic Plasticity and Memory Storage.
The cytoplasmic polyadenylation element-binding protein 3 (CPEB3), a regulator of local protein synthesis, is the mouse homolog of ApCPEB, a functional prion protein in Aplysia. Here, we provide evidence that CPEB3 is activated by Neuralized1, an E3 ubiquitin ligase. In hippocampal cultures, CPEB3 activated by Neuralized1-mediated ubiquitination leads both to the growth of new dendritic spines and to an increase ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NEURL1A CPEB3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| CPEB3 NEURL1A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID