NCSTN
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HERPUD1
Gene Ontology Biological Process
- cellular calcium ion homeostasis [ISO]
- endoplasmic reticulum unfolded protein response [IDA, ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of protein binding [IMP]
- regulation of protein ubiquitination [IMP]
- ubiquitin-dependent protein catabolic process [IDA, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
ER-stress-inducible Herp, facilitates the degradation of immature nicastrin.
Herp is an endoplasmic reticulum (ER)-stress-inducible membrane protein harboring an ubiquitin-like domain (ULD). However, its biological functions are not fully understood. Here, we examined the role of Herp in the degradation of γ-secretase components.Effects of ULD-lacking Herp (ΔUb-Herp) expression on the degradation of γ-secretase components were analyzed.The cellular expression of ΔUb-Herp was found to inhibit the degradation of overexpressed immature ... [more]
Throughput
- Low Throughput
Additional Notes
- source of Herp not clear
- source of nicastrin not clear
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HERPUD1 NCSTN | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 604278 |
Curated By
- BioGRID