BAIT
HIF1A
MOP1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
GO Process (107)
GO Function (19)
GO Component (8)
Gene Ontology Biological Process
- B-1 B cell homeostasis [ISO]
- angiogenesis [ISO]
- axon transport of mitochondrion [ISO, ISS]
- blood vessel development [ISO]
- blood vessel morphogenesis [ISO]
- cardiac ventricle morphogenesis [ISO]
- cartilage development [ISO]
- cell differentiation [ISO]
- cellular iron ion homeostasis [ISO]
- cellular response to carbon monoxide [IEP]
- cellular response to cobalt ion [IEP]
- cellular response to drug [IEP]
- cellular response to electrical stimulus [IEP]
- cellular response to glucose stimulus [IEP]
- cellular response to hydrogen peroxide [IEP]
- cellular response to hypoxia [IEP, IMP, ISO, ISS]
- cellular response to insulin stimulus [IEP]
- cellular response to interleukin-1 [IEP, ISO]
- cellular response to light stimulus [IEP]
- cellular response to lipid [IEP]
- cellular response to lipopolysaccharide [IEP]
- cellular response to mechanical stimulus [IEP]
- cellular response to nitrite [IEP]
- cellular response to organic cyclic compound [IEP]
- cellular response to toxic substance [IEP]
- cerebral cortex development [ISO]
- collagen metabolic process [ISO]
- connective tissue replacement involved in inflammatory response wound healing [ISO]
- digestive tract morphogenesis [ISO]
- dopaminergic neuron differentiation [ISO]
- elastin metabolic process [ISO]
- embryonic hemopoiesis [ISO]
- embryonic placenta development [ISO]
- epithelial cell differentiation involved in mammary gland alveolus development [ISO]
- epithelial to mesenchymal transition [ISO]
- glucose homeostasis [ISO]
- heart looping [ISO]
- hemoglobin biosynthetic process [ISO]
- hypoxia-inducible factor-1alpha signaling pathway [ISO]
- intestinal epithelial cell maturation [ISO]
- lactate metabolic process [ISO]
- lactation [ISO]
- maternal process involved in female pregnancy [IEP]
- muscle cell cellular homeostasis [ISO]
- negative regulation of TOR signaling [ISO]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of bone mineralization [ISO]
- negative regulation of growth [ISO]
- negative regulation of mesenchymal cell apoptotic process [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [ISO]
- negative regulation of thymocyte apoptotic process [ISO]
- negative regulation of transcription elongation from RNA polymerase II promoter [IMP]
- negative regulation of vasoconstriction [IMP]
- neural crest cell migration [ISO]
- neural fold elevation formation [ISO]
- outflow tract morphogenesis [ISO]
- oxygen homeostasis [ISO]
- positive regulation of apoptotic process [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of cell size [IEP]
- positive regulation of epithelial cell migration [ISO]
- positive regulation of erythrocyte differentiation [ISO]
- positive regulation of gene expression [IMP]
- positive regulation of hormone biosynthetic process [ISO]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [ISO]
- positive regulation of neuroblast proliferation [ISO]
- positive regulation of receptor biosynthetic process [ISO]
- positive regulation of smooth muscle cell proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [ISO, ISS]
- positive regulation of transcription, DNA-templated [ISO, ISS]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [ISO]
- positive regulation vascular endothelial growth factor production [ISO, ISS]
- regulation of catalytic activity [ISO]
- regulation of cell proliferation [ISO]
- regulation of cellular response to hypoxia [IEP]
- regulation of gene expression [ISO]
- regulation of glycolytic process [ISO]
- regulation of thymocyte apoptotic process [ISO]
- regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IMP, ISO]
- regulation of transcription, DNA-templated [ISO, TAS]
- regulation of transforming growth factor beta2 production [ISO]
- response to X-ray [IEP]
- response to activity [IEP]
- response to alkaloid [IEP]
- response to anesthetic [IEP]
- response to auditory stimulus [IEP]
- response to cobalt ion [IEP]
- response to drug [IEP]
- response to estradiol [IEP]
- response to estrogen [IEP]
- response to fungicide [IMP]
- response to glucocorticoid [IEP]
- response to glucose [IEP]
- response to hypoxia [IDA, ISO, ISS]
- response to mechanical stimulus [IEP]
- response to muscle activity [ISO]
- response to purine-containing compound [IEP]
- response to salt stress [IEP]
- retina vasculature development in camera-type eye [ISO]
- signal transduction [ISO]
- transcription from RNA polymerase II promoter [ISO]
- vascular endothelial growth factor production [ISO]
- vasculature development [ISO]
- visual learning [ISO]
Gene Ontology Molecular Function- DNA binding [ISO]
- Hsp90 protein binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- RNA polymerase II transcription factor binding transcription factor activity [ISO]
- double-stranded DNA binding [TAS]
- enzyme binding [ISO]
- histone acetyltransferase binding [ISO, ISS]
- histone deacetylase binding [ISO]
- nuclear hormone receptor binding [ISO]
- protein binding [IPI]
- protein complex binding [IMP, IPI]
- protein heterodimerization activity [IDA, ISO, ISS]
- protein kinase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [ISO, ISS]
- transcription factor binding [ISO]
- transcription factor binding transcription factor activity [ISO]
- ubiquitin protein ligase binding [IPI, ISO]
- DNA binding [ISO]
- Hsp90 protein binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- RNA polymerase II transcription factor binding transcription factor activity [ISO]
- double-stranded DNA binding [TAS]
- enzyme binding [ISO]
- histone acetyltransferase binding [ISO, ISS]
- histone deacetylase binding [ISO]
- nuclear hormone receptor binding [ISO]
- protein binding [IPI]
- protein complex binding [IMP, IPI]
- protein heterodimerization activity [IDA, ISO, ISS]
- protein kinase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [ISO, ISS]
- transcription factor binding [ISO]
- transcription factor binding transcription factor activity [ISO]
- ubiquitin protein ligase binding [IPI, ISO]
Rattus norvegicus
PREY
UBC
ubiquitin C
GO Process (2)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
PKB/Akt activation inhibits p53-mediated HIF1A degradation that is independent of MDM2.
Cross-talk between the two transcription factors, p53 and hypoxia inducible factor 1alpha (HIF1A), is important in different pathophysiological conditions (Hammond and Giaccia, 2006, Clin Cancer Res 12:5007-5009) such as in the transition from myocardial hypertrophy to cardiac dilatation and heart failure. In that context, p53 induces HIF1A degradation which in turn provokes the transition from compensatory hypertrophy to myocardial thinning ... [more]
J. Cell. Physiol. Mar. 01, 2010; 222(3);635-9 [Pubmed: 19950214]
Throughput
- Low Throughput
Additional Notes
- likely ubiquitin conjugate
- source of ubiquitin not clear
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HIF1A UBC | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID