GOPC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GRM5
Gene Ontology Biological Process
- G-protein coupled glutamate receptor signaling pathway [IMP, ISO, ISS]
- activation of MAPKKK activity [IDA]
- cognition [ISO]
- desensitization of G-protein coupled receptor protein signaling pathway [IDA]
- learning [ISO]
- locomotory behavior [ISO]
- negative regulation of locomotion [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- phospholipase C-activating G-protein coupled glutamate receptor signaling pathway [TAS]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [TAS]
- positive regulation of long-term neuronal synaptic plasticity [IDA]
- protein kinase C-activating G-protein coupled receptor signaling pathway [IDA, TAS]
- protein phosphorylation [IDA]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of synaptic transmission, glutamatergic [IBA]
- regulation of transcription, DNA-templated [IDA]
- synaptic transmission [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The PDZ domain protein CAL interacts with mGluR5a and modulates receptor expression.
In this study, we investigated the association of metabotropic glutamate receptor subtype-5a (mGluR5a) with cystic fibrosis transmembrane conductance regulator-associated ligand (CAL). Using glutathione-S-transferase pull-down techniques, we found that mGluR5a directly interacted with CAL, with the C-terminus of the receptor binding to the PSD95/Discslarge/ZO-1 homology domain of CAL. The last four amino acids (S-S-S-L) of the C-terminus of the receptor were ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GRM5 GOPC | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| GRM5 GOPC | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID