STX1A
Gene Ontology Biological Process
- calcium ion-dependent exocytosis [IMP]
- intracellular protein transport [IBA]
- positive regulation of exocytosis [ISO]
- positive regulation of neurotransmitter secretion [ISO]
- regulation of exocytosis [ISO]
- response to gravity [ISO]
- secretion by cell [ISO]
- synaptic vesicle fusion to presynaptic membrane [IBA]
- vesicle docking [IBA]
Gene Ontology Molecular Function- ATP-dependent protein binding [ISO]
- SNAP receptor activity [IBA]
- SNARE binding [IDA, ISO]
- calcium channel inhibitor activity [IMP]
- calcium-dependent protein binding [ISO]
- chloride channel inhibitor activity [ISO]
- glycoprotein binding [ISO]
- kinase binding [ISO]
- myosin binding [IBA, ISO]
- myosin head/neck binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein binding, bridging [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- ATP-dependent protein binding [ISO]
- SNAP receptor activity [IBA]
- SNARE binding [IDA, ISO]
- calcium channel inhibitor activity [IMP]
- calcium-dependent protein binding [ISO]
- chloride channel inhibitor activity [ISO]
- glycoprotein binding [ISO]
- kinase binding [ISO]
- myosin binding [IBA, ISO]
- myosin head/neck binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein binding, bridging [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
Gene Ontology Cellular Component
- SNARE complex [ISO]
- actomyosin [ISO]
- cell [IMP]
- endomembrane system [IBA]
- integral component of membrane [IBA]
- intracellular [IBA]
- intracellular organelle [ISO]
- membrane [IDA]
- neuron projection [IDA, ISO]
- plasma membrane [IDA, ISO, TAS]
- protein complex [ISO]
- secretory granule [ISO]
- synaptic vesicle [IDA]
- synaptic vesicle membrane [IDA]
- synaptobrevin 2-SNAP-25-syntaxin-1a complex [IDA, ISO]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex [ISO]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex [ISO]
STX1A
Gene Ontology Biological Process
- calcium ion-dependent exocytosis [IMP]
- intracellular protein transport [IBA]
- positive regulation of exocytosis [ISO]
- positive regulation of neurotransmitter secretion [ISO]
- regulation of exocytosis [ISO]
- response to gravity [ISO]
- secretion by cell [ISO]
- synaptic vesicle fusion to presynaptic membrane [IBA]
- vesicle docking [IBA]
Gene Ontology Molecular Function- ATP-dependent protein binding [ISO]
- SNAP receptor activity [IBA]
- SNARE binding [IDA, ISO]
- calcium channel inhibitor activity [IMP]
- calcium-dependent protein binding [ISO]
- chloride channel inhibitor activity [ISO]
- glycoprotein binding [ISO]
- kinase binding [ISO]
- myosin binding [IBA, ISO]
- myosin head/neck binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein binding, bridging [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- ATP-dependent protein binding [ISO]
- SNAP receptor activity [IBA]
- SNARE binding [IDA, ISO]
- calcium channel inhibitor activity [IMP]
- calcium-dependent protein binding [ISO]
- chloride channel inhibitor activity [ISO]
- glycoprotein binding [ISO]
- kinase binding [ISO]
- myosin binding [IBA, ISO]
- myosin head/neck binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein binding, bridging [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
Gene Ontology Cellular Component
- SNARE complex [ISO]
- actomyosin [ISO]
- cell [IMP]
- endomembrane system [IBA]
- integral component of membrane [IBA]
- intracellular [IBA]
- intracellular organelle [ISO]
- membrane [IDA]
- neuron projection [IDA, ISO]
- plasma membrane [IDA, ISO, TAS]
- protein complex [ISO]
- secretory granule [ISO]
- synaptic vesicle [IDA]
- synaptic vesicle membrane [IDA]
- synaptobrevin 2-SNAP-25-syntaxin-1a complex [IDA, ISO]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex [ISO]
- synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex [ISO]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity.
A neuron forms thousands of presynaptic nerve terminals on its axons, far removed from the cell body. The protein CSPα resides in presynaptic terminals, where it forms a chaperone complex with Hsc70 and SGT. Deletion of CSPα results in massive neurodegeneration that impairs survival in mice and flies. In CSPα-knockout mice, levels of presynaptic SNARE complexes and the SNARE protein ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID