TICAM1
Gene Ontology Biological Process
- MyD88-independent toll-like receptor signaling pathway [IMP]
- apoptotic signaling pathway [IMP]
- defense response to virus [IMP]
- lipopolysaccharide-mediated signaling pathway [IMP]
- macrophage activation involved in immune response [IMP]
- positive regulation of B cell activation [IMP]
- positive regulation of B cell proliferation [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IGI, IMP, ISO]
- positive regulation of NF-kappaB transcription factor activity [IGI, IMP]
- positive regulation of chemokine biosynthetic process [IGI, IMP]
- positive regulation of interferon-beta biosynthetic process [IMP]
- positive regulation of interleukin-6 production [IMP]
- positive regulation of natural killer cell activation [IMP]
- positive regulation of nitric oxide biosynthetic process [IMP]
- positive regulation of protein binding [IDA]
- positive regulation of protein ubiquitination [IDA]
- positive regulation of tumor necrosis factor production [IDA, IGI, IMP]
- positive regulation of type I interferon production [IMP]
- regulation of protein homodimerization activity [IMP]
- response to exogenous dsRNA [IDA, IMP, ISO]
- response to lipopolysaccharide [IGI, IMP]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TRAF3
Gene Ontology Biological Process
- negative regulation of NF-kappaB transcription factor activity [IMP, ISO, TAS]
- regulation of cytokine production [IMP]
- regulation of defense response to virus [IMP]
- regulation of interferon-beta production [IMP]
- regulation of proteolysis [IDA, IMP, ISO]
- toll-like receptor signaling pathway [IMP]
- tumor necrosis factor-mediated signaling pathway [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines.
Balanced production of type I interferons and proinflammatory cytokines after engagement of Toll-like receptors (TLRs), which signal through adaptors containing a Toll-interleukin 1 receptor (TIR) domain, such as MyD88 and TRIF, has been proposed to control the pathogenesis of autoimmune disease and tumor responses to inflammation. Here we show that TRAF3, a ubiquitin ligase that interacts with both MyD88 and ... [more]
Throughput
- Low Throughput
Additional Notes
- source of TRIF not clear
Curated By
- BioGRID