HAP1
Gene Ontology Biological Process
- anterograde axon cargo transport [ISS]
- brain development [NAS]
- negative regulation of beta-amyloid formation [ISS]
- neurotrophin TRK receptor signaling pathway [ISS]
- positive regulation of epidermal growth factor receptor signaling pathway [ISS]
- positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [ISS]
- positive regulation of neurotrophin production [ISS]
- positive regulation of nonmotile primary cilium assembly [ISS]
- positive regulation of synaptic transmission, GABAergic [ISS]
- protein localization [IMP]
- regulation of exocytosis [ISS]
- regulation of organelle transport along microtubule [ISS]
- retrograde axon cargo transport [ISS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HSPA4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Heat shock protein 70 binds to human apurinic/apyrimidinic endonuclease and stimulates endonuclease activity at abasic sites.
The interaction of human heat shock protein 70 (HSP70) with human apurinic/apyrimidinic endonuclease (HAP1) was demonstrated by coimmunoprecipitation. A combination of HSP70 and HAP1 also caused a shift in the electrophoretic mobility of a DNA fragment containing an apurinic/apyrimidinic site. The functional consequence of the HSP70/HAP1 interaction was a 10-100-fold enhancement of endonuclease activity at abasic sites. The physical and ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID