BAIT
SVIL
RP11-534G20.1
supervillin
GO Process (2)
GO Function (2)
GO Component (9)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CENPF
CENF, PRO1779, hcp-1, RP11-262H5.1
centromere protein F, 350/400kDa
GO Process (13)
GO Function (6)
GO Component (13)
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [TAS]
- cell proliferation [NAS]
- chromosome segregation [IMP, NAS]
- kinetochore assembly [NAS]
- metaphase plate congression [IDA]
- mitotic cell cycle [IMP, TAS]
- mitotic spindle assembly checkpoint [NAS]
- negative regulation of transcription, DNA-templated [IDA]
- protein transport [IDA, IMP]
- regulation of G2/M transition of mitotic cell cycle [IMP]
- regulation of cell cycle [TAS]
- regulation of striated muscle tissue development [ISS]
- response to drug [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Novel interactors and a role for supervillin in early cytokinesis.
Supervillin, the largest member of the villin/gelsolin/flightless family, is a peripheral membrane protein that regulates each step of cell motility, including cell spreading. Most known interactors bind within its amino (N)-terminus. We show here that the supervillin carboxy (C)-terminus can be modeled as supervillin-specific loops extending from gelsolin-like repeats plus a villin-like headpiece. We have identified 27 new candidate interactors ... [more]
Cytoskeleton (Hoboken) Jun. 01, 2010; 67(6);346-64 [Pubmed: 20309963]
Throughput
- Low Throughput
Curated By
- BioGRID