BAIT
SVIL
RP11-534G20.1
supervillin
GO Process (2)
GO Function (2)
GO Component (9)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NME2
NDKB, NDPK-B, NDPKB, NM23-H2, NM23B, PUF
NME/NM23 nucleoside diphosphate kinase 2
GO Process (12)
GO Function (3)
GO Component (8)
Gene Ontology Biological Process
- cell adhesion [TAS]
- integrin-mediated signaling pathway [IDA]
- negative regulation of apoptotic process [IMP]
- nucleobase-containing small molecule interconversion [TAS]
- nucleobase-containing small molecule metabolic process [TAS]
- nucleoside triphosphate biosynthetic process [IDA]
- positive regulation of epithelial cell proliferation [IMP]
- positive regulation of keratinocyte differentiation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of epidermis development [IMP]
- regulation of transcription, DNA-templated [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Novel interactors and a role for supervillin in early cytokinesis.
Supervillin, the largest member of the villin/gelsolin/flightless family, is a peripheral membrane protein that regulates each step of cell motility, including cell spreading. Most known interactors bind within its amino (N)-terminus. We show here that the supervillin carboxy (C)-terminus can be modeled as supervillin-specific loops extending from gelsolin-like repeats plus a villin-like headpiece. We have identified 27 new candidate interactors ... [more]
Cytoskeleton (Hoboken) Jun. 01, 2010; 67(6);346-64 [Pubmed: 20309963]
Throughput
- Low Throughput
Curated By
- BioGRID