BAIT
GSK3B
glycogen synthase kinase 3 beta
GO Process (56)
GO Function (17)
GO Component (19)
Gene Ontology Biological Process
- ER overload response [ISO]
- Wnt signaling pathway [ISO]
- axonogenesis [ISO]
- canonical Wnt signaling pathway [ISO]
- canonical Wnt signaling pathway involved in positive regulation of apoptotic process [ISO]
- cell migration [ISO]
- cellular response to interleukin-3 [ISO, ISS]
- cellular response to mechanical stimulus [IDA]
- circadian rhythm [ISO, ISS]
- epithelial to mesenchymal transition [ISO, ISS]
- establishment of cell polarity [IDA]
- establishment or maintenance of cell polarity [IDA]
- extrinsic apoptotic signaling pathway in absence of ligand [ISO, ISS]
- fat cell differentiation [ISO]
- glycogen metabolic process [ISO]
- hippocampus development [ISO]
- hypermethylation of CpG island [ISO]
- intracellular signal transduction [ISO]
- myoblast fusion [ISO]
- myotube differentiation [ISO]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of NFAT protein import into nucleus [ISO, ISS]
- negative regulation of apoptotic process [ISO]
- negative regulation of cardiac muscle hypertrophy [ISO]
- negative regulation of dendrite morphogenesis [IMP]
- negative regulation of neuron maturation [ISO]
- negative regulation of neuron projection development [ISO]
- negative regulation of protein binding [ISO]
- negative regulation of protein complex assembly [ISO]
- organ morphogenesis [ISO]
- peptidyl-serine phosphorylation [ISO, ISS]
- phosphorylation [ISO]
- positive regulation of Rac GTPase activity [ISO]
- positive regulation of apoptotic process [IDA, IMP]
- positive regulation of axon extension [ISO]
- positive regulation of cell-matrix adhesion [ISO]
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [ISO, ISS]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of peptidyl-threonine phosphorylation [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein binding [ISO, ISS]
- positive regulation of protein complex assembly [ISO]
- positive regulation of protein export from nucleus [ISO]
- positive regulation of stem cell differentiation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein export from nucleus [ISO]
- protein localization to microtubule [ISO]
- protein phosphorylation [IDA, ISO]
- re-entry into mitotic cell cycle [ISO]
- regulation of gene expression by genetic imprinting [ISO]
- regulation of microtubule-based process [ISO, ISS]
- regulation of neuron projection development [ISO]
- regulation of neuronal synaptic plasticity [IMP]
- response to drug [IEP]
- response to lithium ion [IEP]
- superior temporal gyrus development [ISO]
Gene Ontology Molecular Function- ATP binding [IDA]
- NF-kappaB binding [ISO]
- RNA polymerase II transcription factor binding [ISO]
- beta-catenin binding [ISO]
- integrin binding [IPI]
- ionotropic glutamate receptor binding [IPI]
- kinase activity [ISO, ISS]
- p53 binding [ISO]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [ISO]
- protein kinase activity [ISO]
- protein kinase binding [IPI, ISO]
- protein serine/threonine kinase activity [IDA, ISO, TAS]
- tau protein binding [IDA]
- tau-protein kinase activity [IDA, ISO]
- transcription factor binding [IPI]
- ubiquitin protein ligase binding [ISO]
- ATP binding [IDA]
- NF-kappaB binding [ISO]
- RNA polymerase II transcription factor binding [ISO]
- beta-catenin binding [ISO]
- integrin binding [IPI]
- ionotropic glutamate receptor binding [IPI]
- kinase activity [ISO, ISS]
- p53 binding [ISO]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [ISO]
- protein kinase activity [ISO]
- protein kinase binding [IPI, ISO]
- protein serine/threonine kinase activity [IDA, ISO, TAS]
- tau protein binding [IDA]
- tau-protein kinase activity [IDA, ISO]
- transcription factor binding [IPI]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- beta-catenin destruction complex [IDA, ISO]
- cell body [ISO]
- centrosome [ISO]
- cytoplasm [IDA, ISO, ISS, TAS]
- cytosol [IDA, ISO, TAS]
- dendritic shaft [ISO]
- dendritic spine [IDA]
- growth cone [ISO]
- membrane [IDA]
- membrane raft [IDA]
- membrane-bounded organelle [ISO]
- neuronal cell body [ISO]
- neuronal postsynaptic density [ISO]
- nucleoplasm [ISO]
- nucleus [IDA, ISO, ISS]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- protein complex [IDA]
- ribonucleoprotein complex [ISO]
Rattus norvegicus
PREY
APC
RATAPC
adenomatous polyposis coli
GO Process (63)
GO Function (10)
GO Component (30)
Gene Ontology Biological Process
- T cell differentiation in thymus [ISO]
- Wnt signaling pathway [ISO]
- anterior/posterior pattern specification [ISO]
- axis specification [ISO]
- axonogenesis [ISO]
- canonical Wnt signaling pathway [ISO]
- canonical Wnt signaling pathway involved in negative regulation of apoptotic process [ISO]
- canonical Wnt signaling pathway involved in positive regulation of apoptotic process [ISO]
- cell cycle arrest [ISO, ISS]
- cell migration [ISO, ISS]
- cellular response to DNA damage stimulus [ISO, ISS]
- cellular response to nerve growth factor stimulus [IEP]
- chromosome organization [ISO]
- cytoplasmic microtubule organization [ISO]
- dorsal/ventral pattern formation [ISO]
- establishment or maintenance of cell polarity [IDA]
- hair follicle development [ISO]
- kidney development [ISO]
- metaphase/anaphase transition of mitotic cell cycle [ISO]
- mitotic cytokinesis [ISO]
- mitotic spindle assembly checkpoint [ISO]
- muscle cell cellular homeostasis [ISO]
- negative regulation of MAPK cascade [ISO]
- negative regulation of Wnt signaling pathway [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of canonical Wnt signaling pathway [ISO]
- negative regulation of cell proliferation [ISO, ISS]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [ISO, ISS]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of epithelial cell proliferation involved in prostate gland development [ISO]
- negative regulation of microtubule depolymerization [ISO, ISS]
- negative regulation of odontogenesis [ISO]
- neuron projection development [IMP]
- pancreas development [IEP]
- pattern specification process [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell adhesion [ISO]
- positive regulation of cell differentiation [ISO]
- positive regulation of cell division [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of epithelial cell differentiation [ISO]
- positive regulation of microtubule polymerization [ISO]
- positive regulation of protein catabolic process [ISO]
- positive regulation of pseudopodium assembly [ISO]
- protein complex assembly [ISO, ISS]
- proximal/distal pattern formation [ISO]
- regulation of attachment of spindle microtubules to kinetochore [ISO]
- regulation of cell cycle [ISO]
- regulation of cell differentiation [ISO]
- regulation of cell migration [ISO]
- regulation of epithelial cell differentiation [ISO]
- regulation of glutamate metabolic process [IDA]
- regulation of microtubule-based process [ISO, ISS]
- regulation of nitrogen compound metabolic process [ISO]
- regulation of osteoblast differentiation [ISO]
- regulation of osteoclast differentiation [ISO]
- response to alcohol [IEP]
- response to drug [IEP]
- retina development in camera-type eye [ISO]
- skin development [ISO]
- somatic stem cell maintenance [ISO]
- stem cell maintenance [ISO]
- thymus development [ISO]
Gene Ontology Molecular Function- beta-catenin binding [ISO, ISS]
- cadherin binding [ISO]
- gamma-catenin binding [ISO]
- microtubule binding [IDA, IMP, ISO, ISS]
- microtubule plus-end binding [ISO, ISS]
- protease binding [ISO]
- protein binding [IPI]
- protein complex binding [IDA]
- protein kinase binding [ISO]
- protein kinase regulator activity [ISO, ISS]
- beta-catenin binding [ISO, ISS]
- cadherin binding [ISO]
- gamma-catenin binding [ISO]
- microtubule binding [IDA, IMP, ISO, ISS]
- microtubule plus-end binding [ISO, ISS]
- protease binding [ISO]
- protein binding [IPI]
- protein complex binding [IDA]
- protein kinase binding [ISO]
- protein kinase regulator activity [ISO, ISS]
Gene Ontology Cellular Component
- Scrib-APC-beta-catenin complex [ISO]
- axon [ISO]
- axonal growth cone [IDA, ISO]
- beta-catenin destruction complex [ISO, ISS]
- cell [ISO]
- cell body fiber [IDA]
- cell cortex [IDA]
- cell projection [ISO]
- cell projection membrane [ISO]
- cell-cell adherens junction [ISO, ISS]
- centrosome [ISO, ISS]
- cytoplasm [IDA, ISO, ISS]
- cytoplasmic microtubule [ISO]
- dendrite [IDA]
- growth cone [IDA, ISO]
- kinetochore [ISO, ISS]
- lamellipodium [IDA, ISO, ISS]
- lateral plasma membrane [ISO]
- microtubule [IDA]
- microtubule plus-end [ISO]
- neuron projection [IDA]
- neuron projection terminus [IDA]
- neuronal cell body [IDA]
- nuclear membrane [IDA]
- nucleus [IDA, ISO, ISS]
- plasma membrane [ISO, ISS]
- protein complex [IDA]
- ruffle membrane [ISO, ISS]
- synapse [IDA]
- tight junction [ISO]
Rattus norvegicus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Delta-catenin/NPRAP: A new member of the glycogen synthase kinase-3beta signaling complex that promotes beta-catenin turnover in neurons.
Through a multiprotein complex, glycogen synthase kinase-3beta (GSK-3beta) phosphorylates and destabilizes beta-catenin, an important signaling event for neuronal growth and proper synaptic function. delta-Catenin, or NPRAP (CTNND2), is a neural enriched member of the beta-catenin superfamily and is also known to modulate neurite outgrowth and synaptic activity. In this study, we investigated the possibility that delta-catenin expression is also affected ... [more]
J. Neurosci. Res. Aug. 15, 2010; 88(11);2350-63 [Pubmed: 20623542]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| APC GSK3B | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID