TNNT2
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- actin crosslink formation [IDA]
- atrial cardiac muscle tissue morphogenesis [ISO]
- cardiac muscle contraction [IDA]
- heart development [ISO]
- muscle contraction [IMP, ISO, TAS]
- muscle filament sliding [ISO, ISS]
- negative regulation of ATPase activity [ISO, ISS]
- positive regulation of ATPase activity [ISO, ISS]
- protein heterooligomerization [IPI]
- regulation of heart contraction [ISO, ISS]
- regulation of muscle contraction [IDA]
- regulation of muscle filament sliding speed [IMP]
- response to calcium ion [ISO, ISS]
- sarcomere organization [ISO]
- ventricular cardiac muscle tissue morphogenesis [ISO, ISS]
Gene Ontology Molecular Function
UBC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Neuregulin-1 attenuated doxorubicin-induced decrease in cardiac troponins.
Neuregulin-1 (NRG1) is a potential therapeutic agent for the treatment of doxorubicin (Dox)-induced heart failure. NRG1, however, activates the erbB2 receptor, which is frequently overexpressed in breast cancers. It is, therefore, important to understand how NRG1, via erbB2, protects the heart against Dox cardiotoxicity. Here, we studied NRG1-erbB2 signaling in Dox-treated mice hearts and in isolated neonatal rat ventricular myocytes ... [more]
Throughput
- Low Throughput
Additional Notes
- likely ubiquitin conjugate
Curated By
- BioGRID