ITCH
Gene Ontology Biological Process
- negative regulation of JNK cascade [IMP]
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of alpha-beta T cell proliferation [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of defense response to virus [IMP, ISO]
- positive regulation of T cell anergy [IMP]
- positive regulation of protein catabolic process [IDA, IMP]
- protein K29-linked ubiquitination [ISO]
- protein K48-linked ubiquitination [IMP, ISO]
- protein K63-linked ubiquitination [ISO]
- protein polyubiquitination [IDA]
- protein ubiquitination [IBA, ISO]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- regulation of protein deubiquitination [IMP]
- ubiquitin-dependent protein catabolic process [IDA, ISA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PTPN11
Gene Ontology Biological Process
- DNA damage checkpoint [IMP]
- ERBB signaling pathway [ISO]
- abortive mitotic cell cycle [IMP]
- activation of MAPK activity [IMP]
- atrioventricular canal development [ISO]
- axonogenesis [IMP]
- brain development [ISO]
- dephosphorylation [IMP]
- ephrin receptor signaling pathway [ISO]
- epidermal growth factor receptor signaling pathway [IGI]
- face morphogenesis [ISO]
- genitalia development [ISO]
- glucose homeostasis [IMP]
- heart development [ISO]
- hormone metabolic process [IMP]
- hormone-mediated signaling pathway [IDA]
- inner ear development [ISO]
- integrin-mediated signaling pathway [IMP]
- lipid metabolic process [IMP]
- megakaryocyte development [IMP]
- multicellular organismal reproductive process [IMP]
- negative regulation of cell adhesion mediated by integrin [IMP]
- negative regulation of cortisol secretion [IMP]
- negative regulation of growth hormone secretion [IMP]
- negative regulation of hormone secretion [IMP]
- negative regulation of insulin secretion [IMP]
- neurotrophin TRK receptor signaling pathway [IMP]
- organ growth [IMP]
- peptidyl-tyrosine dephosphorylation [IDA, ISO]
- platelet formation [IGI]
- platelet-derived growth factor receptor signaling pathway [IGI]
- positive regulation of ERK1 and ERK2 cascade [IGI]
- positive regulation of glucose import in response to insulin stimulus [ISO]
- positive regulation of hormone secretion [IMP]
- positive regulation of mitotic cell cycle [IGI]
- positive regulation of signal transduction [IMP, ISO]
- protein dephosphorylation [ISO]
- regulation of cell adhesion mediated by integrin [ISO]
- regulation of multicellular organism growth [IMP]
- regulation of protein export from nucleus [IMP]
- triglyceride metabolic process [IMP]
Gene Ontology Molecular Function- D1 dopamine receptor binding [ISO]
- SH3/SH2 adaptor activity [ISO]
- insulin receptor binding [ISO]
- insulin receptor substrate binding [ISO]
- non-membrane spanning protein tyrosine phosphatase activity [ISO]
- peptide hormone receptor binding [IPI]
- phospholipase binding [ISO]
- phosphoprotein phosphatase activity [IMP, ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein tyrosine phosphatase activity [IDA, ISO]
- receptor tyrosine kinase binding [IPI]
- D1 dopamine receptor binding [ISO]
- SH3/SH2 adaptor activity [ISO]
- insulin receptor binding [ISO]
- insulin receptor substrate binding [ISO]
- non-membrane spanning protein tyrosine phosphatase activity [ISO]
- peptide hormone receptor binding [IPI]
- phospholipase binding [ISO]
- phosphoprotein phosphatase activity [IMP, ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein tyrosine phosphatase activity [IDA, ISO]
- receptor tyrosine kinase binding [IPI]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
CTLA-4 (CD152) inhibits T cell function by activating the ubiquitin ligase Itch.
CTLA-4 (CD152) is a regulatory molecule in the immune system fundamentally important for the inhibition of T cell activity that is mediated by an unknown mechanism. Here we demonstrate similarities of CTLA-4 and Itch deficient mice and that CTLA-4 deficient T cells show a massive reduction in the overall ubiquitination of proteins. CTLA-4-mediated signal transduction leads to increased de-phosphorylation and ... [more]
Throughput
- Low Throughput
Additional Notes
- source of proteins not clear
Curated By
- BioGRID