ESR2
Gene Ontology Biological Process
- Sertoli cell development [IEP]
- Sertoli cell proliferation [IMP]
- amygdala development [IEP]
- behavioral fear response [IDA]
- brain development [ISO]
- cellular response to drug [IEP]
- cellular response to estradiol stimulus [IEP]
- cellular response to magnetism [IEP]
- cellular response to organic cyclic compound [IEP]
- cerebellum development [IEP]
- epithelial cell maturation involved in prostate gland development [ISO]
- estrus [IMP]
- female gonad development [IEP]
- hormone-mediated apoptotic signaling pathway [ISO]
- hypothalamus development [IEP]
- intracellular estrogen receptor signaling pathway [ISO, TAS]
- intracellular steroid hormone receptor signaling pathway [IDA]
- learning or memory [IMP]
- male gonad development [IEP]
- negative regulation of androgen receptor signaling pathway [ISO]
- negative regulation of behavior [IDA]
- negative regulation of cell death [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of epithelial cell proliferation [IDA, ISO]
- negative regulation of feeding behavior [IMP]
- negative regulation of neuron death [IDA]
- negative regulation of reactive oxygen species metabolic process [IMP]
- negative regulation of smooth muscle cell proliferation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- neuron migration [ISO]
- ovarian follicle development [IEP, ISO]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of apoptotic process [IDA]
- positive regulation of epidermal growth factor receptor signaling pathway [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO, ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- prostate gland development [IEP]
- prostate gland epithelium morphogenesis [ISO]
- regulation of cell proliferation [ISO]
- regulation of neuron apoptotic process [IDA]
- response to activity [IEP]
- response to dexamethasone [IEP]
- response to drug [IEP]
- response to estradiol [IEP]
- response to estrogen [IEP]
- response to ethanol [IEP]
- response to genistein [IEP]
- response to hormone [IEP]
- response to human chorionic gonadotropin [IEP]
- response to insecticide [IEP]
- response to nutrient levels [IEP]
- response to organic cyclic compound [IEP]
- response to salt [IEP]
- response to testosterone [IEP, IMP]
- response to water deprivation [IEP]
- uterus development [ISO]
- vagina development [ISO]
Gene Ontology Molecular Function- DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- core promoter sequence-specific DNA binding [IDA, ISO]
- drug binding [IPI]
- enzyme binding [IPI, ISO]
- estrogen receptor activity [IDA, IMP]
- estrogen response element binding [IDA, ISO]
- hormone binding [IDA, IMP, IPI]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- peroxisome proliferator activated receptor binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- steroid binding [IDA]
- steroid hormone binding [IPI]
- steroid hormone receptor activity [IDA]
- DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- core promoter sequence-specific DNA binding [IDA, ISO]
- drug binding [IPI]
- enzyme binding [IPI, ISO]
- estrogen receptor activity [IDA, IMP]
- estrogen response element binding [IDA, ISO]
- hormone binding [IDA, IMP, IPI]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- peroxisome proliferator activated receptor binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- steroid binding [IDA]
- steroid hormone binding [IPI]
- steroid hormone receptor activity [IDA]
Gene Ontology Cellular Component
UBC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection.
Recent work suggests that timing of 17β-estradiol (E2) therapy may be critical for observing a beneficial neural effect. Along these lines, E2 neuroprotection, but not its uterotropic effect, was shown to be lost following long-term E2 deprivation (LTED), and this effect was associated with a significant decrease of estrogen receptor-α (ERα) in the hippocampus but not the uterus. The purpose ... [more]
Throughput
- Low Throughput
Additional Notes
- likely ubiquitin conjugate
Curated By
- BioGRID