PRKCG
Gene Ontology Biological Process
- activation of phospholipase C activity [TAS]
- blood coagulation [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of proteasomal protein catabolic process [ISS]
- negative regulation of protein catabolic process [IDA]
- negative regulation of protein ubiquitination [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphorylation [IDA]
- platelet activation [TAS]
- positive regulation of mismatch repair [IDA]
- protein phosphorylation [TAS]
- regulation of circadian rhythm [ISS]
- regulation of response to food [ISS]
- response to morphine [ISS]
- response to pain [ISS]
- signal transduction [TAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DDX58
Gene Ontology Biological Process
- RIG-I signaling pathway [IMP]
- cytoplasmic pattern recognition receptor signaling pathway in response to virus [TAS]
- detection of virus [IDA]
- innate immune response [IMP, TAS]
- negative regulation of type I interferon production [TAS]
- positive regulation of defense response to virus by host [IMP]
- positive regulation of interferon-alpha production [IDA, IMP]
- positive regulation of interferon-beta production [IDA, IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IC]
- positive regulation of transcription factor import into nucleus [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of cell migration [IDA]
- regulation of type III interferon production [TAS]
- response to virus [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Conventional PKC-α/β Negatively Regulate RIG-I Antiviral Signal Transduction.
Retinoic acid-inducible gene-I (RIG-I) is a key sensor for viral RNA in the cytosol and initiates a signaling cascade leading to the establishment of an interferon (IFN)-mediated antiviral state. Because of its integral role in immune signaling, RIG-I activity must be precisely controlled. Recent studies have shown that RIG-I CARD-dependent signaling function is regulated by the dynamic balance between phosphorylation ... [more]
Throughput
- Low Throughput
Additional Notes
- RIG-I is phosphorylated in vitro in the presence of PKC alpha/beta/gamma
Curated By
- BioGRID