BAIT
GRIN1
GluN1, NMDAR1, NR1
glutamate receptor, ionotropic, N-methyl D-aspartate 1
GO Process (55)
GO Function (17)
GO Component (18)
Gene Ontology Biological Process
- adult locomotory behavior [ISO]
- associative learning [ISO]
- calcium ion homeostasis [ISO]
- calcium ion transmembrane transport [ISO]
- calcium ion transport [ISO]
- cation transport [ISO]
- cellular calcium ion homeostasis [ISO]
- cellular response to manganese ion [IEP]
- cerebral cortex development [ISO]
- conditioned taste aversion [ISO]
- ion transmembrane transport [IBA, ISO]
- ionotropic glutamate receptor signaling pathway [IDA, ISO]
- learning [ISO]
- learning or memory [ISO, TAS]
- long-term memory [ISO]
- male mating behavior [ISO]
- memory [ISO]
- negative regulation of neuron apoptotic process [ISO]
- neuromuscular process [ISO]
- olfactory learning [ISO]
- pons maturation [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell death [IDA]
- positive regulation of excitatory postsynaptic membrane potential [IDA]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- prepulse inhibition [ISO]
- propylene metabolic process [ISO]
- protein tetramerization [IDA]
- regulation of axonogenesis [ISO]
- regulation of cell communication [ISO]
- regulation of dendrite morphogenesis [ISO]
- regulation of excitatory postsynaptic membrane potential [ISO]
- regulation of ion transmembrane transport [IMP]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of membrane potential [ISO]
- regulation of neuron apoptotic process [ISO]
- regulation of neuronal synaptic plasticity [ISO]
- regulation of respiratory gaseous exchange [ISO]
- regulation of synapse assembly [ISO]
- regulation of synaptic plasticity [ISO]
- respiratory gaseous exchange [ISO]
- response to amine [IEP]
- response to amphetamine [ISO]
- response to calcium ion [IEP]
- response to ethanol [ISO]
- response to fungicide [IEP]
- response to morphine [ISO]
- response to organic cyclic compound [IEP]
- rhythmic process [IDA]
- sensory perception of pain [ISO]
- social behavior [ISO]
- startle response [ISO]
- suckling behavior [ISO]
- synaptic transmission, glutamatergic [IBA, ISO]
- visual learning [ISO]
Gene Ontology Molecular Function- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IGI, IMP, ISO, TAS]
- calcium channel activity [ISO]
- calcium ion binding [ISO]
- calmodulin binding [ISO]
- cation channel activity [ISO]
- enzyme binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate binding [IDA, ISO]
- glutamate receptor binding [IPI]
- glycine binding [IDA, ISO]
- ionotropic glutamate receptor activity [IDA, TAS]
- neurotransmitter binding [IDA]
- protein binding [IPI]
- protein dimerization activity [IDA]
- protein heterodimerization activity [IDA]
- receptor binding [IPI, ISO]
- voltage-gated cation channel activity [IMP]
- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IGI, IMP, ISO, TAS]
- calcium channel activity [ISO]
- calcium ion binding [ISO]
- calmodulin binding [ISO]
- cation channel activity [ISO]
- enzyme binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate binding [IDA, ISO]
- glutamate receptor binding [IPI]
- glycine binding [IDA, ISO]
- ionotropic glutamate receptor activity [IDA, TAS]
- neurotransmitter binding [IDA]
- protein binding [IPI]
- protein dimerization activity [IDA]
- protein heterodimerization activity [IDA]
- receptor binding [IPI, ISO]
- voltage-gated cation channel activity [IMP]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IDA, ISO, TAS]
- cell [ISO]
- cell surface [ISO]
- cytoplasm [ISO]
- dendrite [ISO]
- dendrite membrane [IDA]
- dendritic spine [IDA, ISO]
- endoplasmic reticulum [ISO]
- excitatory synapse [IDA]
- integral component of plasma membrane [ISO]
- membrane [ISO]
- neuronal postsynaptic density [ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IBA, ISO]
- synapse [IDA, ISO]
- synaptic cleft [IDA]
- synaptic vesicle [ISO]
- terminal bouton [IDA]
Rattus norvegicus
PREY
DRD1
D1a, Drd-1, Drd1a
dopamine receptor D1
GO Process (83)
GO Function (14)
GO Component (16)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [ISO]
- activation of adenylate cyclase activity [IDA, ISO]
- adenylate cyclase-activating G-protein coupled receptor signaling pathway [ISO]
- adenylate cyclase-activating dopamine receptor signaling pathway [IDA, ISO]
- adult walking behavior [ISO]
- associative learning [IEP, IMP, ISO]
- astrocyte development [ISO]
- behavioral fear response [ISO]
- behavioral response to cocaine [IMP, ISO]
- calcium-mediated signaling [IDA]
- cellular response to catecholamine stimulus [ISO]
- cellular response to hypoxia [IEP]
- cellular response to insulin stimulus [IEP]
- cerebral cortex GABAergic interneuron migration [ISO]
- conditioned taste aversion [ISO]
- dentate gyrus development [ISO]
- dopamine receptor signaling pathway [IDA, IMP, ISO, TAS]
- dopamine transport [ISO]
- feeding behavior [ISO]
- glucose import [ISO]
- grooming behavior [ISO]
- habituation [ISO]
- hippocampus development [ISO]
- intracellular protein transport [IMP]
- learning [ISO]
- locomotory behavior [IMP, ISO]
- long term synaptic depression [ISO]
- long-term synaptic potentiation [ISO]
- maternal behavior [ISO]
- mating behavior [ISO]
- memory [ISO]
- muscle contraction [ISO]
- negative regulation of cell migration [IMP]
- negative regulation of circadian sleep/wake cycle, sleep [IDA]
- negative regulation of protein kinase activity [IMP]
- neuronal action potential [ISO]
- operant conditioning [IMP, ISO]
- orbitofrontal cortex development [IEP]
- peristalsis [ISO]
- phosphatidylinositol catabolic process [IDA]
- phosphatidylinositol metabolic process [IDA]
- phospholipase C-activating dopamine receptor signaling pathway [ISO]
- positive regulation of adenylate cyclase activity [IDA]
- positive regulation of cAMP biosynthetic process [IDA, IMP, ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [ISO]
- positive regulation of feeding behavior [IMP]
- positive regulation of long-term synaptic potentiation [IMP]
- positive regulation of membrane potential [IMP]
- positive regulation of release of sequestered calcium ion into cytosol [ISO]
- positive regulation of synaptic transmission, glutamatergic [ISO]
- prepulse inhibition [ISO]
- protein import into nucleus [ISO]
- regulation of dopamine metabolic process [ISO]
- regulation of ion transport [IDA]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of vasoconstriction [IMP]
- response to activity [IEP]
- response to amino acid [IEP]
- response to amphetamine [IEP, ISO]
- response to antidepressant [IEP]
- response to cocaine [ISO]
- response to drug [IEP, ISO]
- response to estradiol [IEP]
- response to ethanol [IEP]
- response to food [IEP]
- response to morphine [IEP]
- response to nicotine [IEP]
- response to organic cyclic compound [IEP]
- response to organonitrogen compound [IEP]
- response to retinoic acid [IEP]
- response to steroid hormone [IEP]
- sensitization [ISO]
- social behavior [IMP]
- startle response [ISO]
- striatum development [IEP, ISO]
- synapse assembly [IEP]
- synaptic transmission [ISO]
- synaptic transmission, dopaminergic [IDA, IMP, ISO]
- temperature homeostasis [ISO]
- transmission of nerve impulse [ISO]
- visual learning [IMP, ISO]
Gene Ontology Molecular Function- ATPase binding [IPI]
- D3 dopamine receptor binding [IPI]
- G-protein alpha-subunit binding [IPI]
- G-protein coupled receptor activity [IDA, ISO]
- angiotensin receptor binding [IPI]
- dopamine binding [ISO]
- dopamine neurotransmitter receptor activity [ISO]
- dopamine neurotransmitter receptor activity, coupled via Gs [IDA, IMP, ISO]
- drug binding [IDA]
- protein binding [IPI]
- protein complex binding [IPI]
- protein heterodimerization activity [IPI]
- protein phosphatase binding [IPI]
- receptor binding [IPI]
- ATPase binding [IPI]
- D3 dopamine receptor binding [IPI]
- G-protein alpha-subunit binding [IPI]
- G-protein coupled receptor activity [IDA, ISO]
- angiotensin receptor binding [IPI]
- dopamine binding [ISO]
- dopamine neurotransmitter receptor activity [ISO]
- dopamine neurotransmitter receptor activity, coupled via Gs [IDA, IMP, ISO]
- drug binding [IDA]
- protein binding [IPI]
- protein complex binding [IPI]
- protein heterodimerization activity [IPI]
- protein phosphatase binding [IPI]
- receptor binding [IPI]
Gene Ontology Cellular Component
- axon [IDA]
- axon terminus [IDA]
- caveola [IDA]
- cell [ISO]
- dendrite [IDA]
- dendritic shaft [IDA]
- dendritic spine [IDA]
- dendritic spine head [IDA]
- dendritic spine neck [IDA]
- endoplasmic reticulum [IDA]
- integral component of membrane [IDA]
- intracellular [ISO]
- membrane [ISO]
- neuronal cell body [IDA]
- nucleus [ISO]
- plasma membrane [IDA, ISO]
Rattus norvegicus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Dual regulation of NMDA receptor functions by direct protein-protein interactions with the dopamine D1 receptor.
Dopamine D1-like receptors, composed of D1 and D5 receptors, have been documented to modulate glutamate-mediated fast excitatory synaptic neurotransmission. Here, we report that dopamine D1 receptors modulate NMDA glutamate receptor-mediated functions through direct protein-protein interactions. Two regions in the D1 receptor carboxyl tail can directly and selectively couple to NMDA glutamate receptor subunits NR1-1a and NR2A. While one interaction is ... [more]
Cell Oct. 18, 2002; 111(2);219-30 [Pubmed: 12408866]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DRD1 GRIN1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| DRD1 GRIN1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID