BAIT
CUL5
4921514I20Rik, 8430423K24Rik, AI852817, C030032G03Rik, C330021I08Rik, VACM-1, VACM1
cullin 5
GO Process (4)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SOCS5
1810018L08Rik, Cish5, mKIAA0671
suppressor of cytokine signaling 5
GO Process (14)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- cell growth [NAS]
- cytokine-mediated signaling pathway [IDA]
- epidermal growth factor receptor signaling pathway [IDA]
- negative regulation of JAK-STAT cascade [IBA]
- negative regulation of T-helper 2 cell differentiation [IDA]
- negative regulation of catalytic activity [NAS]
- negative regulation of epidermal growth factor receptor signaling pathway [IBA]
- negative regulation of epidermal growth factor-activated receptor activity [ISO]
- negative regulation of phosphorylation [NAS]
- negative regulation of protein kinase activity [IBA]
- negative regulation of signal transduction [NAS]
- positive regulation of T-helper 1 cell differentiation [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytoplasm [IBA, NAS]
- intracellular [TAS]
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression.
The SOCS (suppressors of cytokine signalling) family of proteins inhibits the cytokine-induced signalling cascade in part by promoting the ubiquitination of signalling intermediates that are then targeted for proteasomal degradation. This activity relies upon an interaction between the SOCS box domain, the adapter complex elonginBC and a member of the Cullin family, the scaffold protein of an E3 ubiquitin ligase. ... [more]
J. Mol. Biol. Mar. 20, 2009; 387(1);162-74 [Pubmed: 19385048]
Throughput
- Low Throughput
Curated By
- BioGRID