IDO1
Gene Ontology Biological Process
- cytokine production involved in inflammatory response [IMP]
- defense response [TAS]
- inflammatory response [IMP]
- kynurenic acid biosynthetic process [IMP]
- multicellular organismal response to stress [IMP]
- negative regulation of T cell apoptotic process [IMP]
- negative regulation of T cell proliferation [IMP]
- negative regulation of activated T cell proliferation [IMP]
- negative regulation of interleukin-10 production [IMP]
- oxidation-reduction process [IDA]
- positive regulation of T cell apoptotic process [ISO]
- positive regulation of T cell tolerance induction [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of chronic inflammatory response [IMP]
- positive regulation of interleukin-12 production [IMP]
- positive regulation of type 2 immune response [IMP]
- response to lipopolysaccharide [IMP]
- swimming behavior [IMP]
- tryptophan catabolic process to kynurenine [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SOCS3
Gene Ontology Biological Process
- JAK-STAT cascade [ISO]
- branching involved in labyrinthine layer morphogenesis [IMP]
- cytokine-mediated signaling pathway [IBA]
- intracellular signal transduction [ISO]
- negative regulation of JAK-STAT cascade [IBA]
- negative regulation of inflammatory response [IGI]
- negative regulation of insulin receptor signaling pathway [IDA]
- negative regulation of protein kinase activity [IBA]
- negative regulation of signal transduction [IGI]
- placenta blood vessel development [IMP]
- positive regulation of cell differentiation [IDA, IGI]
- regulation of cell differentiation [IGI, IMP]
- regulation of protein phosphorylation [IDA]
- signal transduction [ISO]
- spongiotrophoblast differentiation [IGI, IMP]
- trophoblast giant cell differentiation [IGI, IMP]
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis.
Despite their common ability to activate intracellular signaling through CD80/CD86 molecules, cytotoxic T lymphocyte antigen 4 (CTLA-4)-Ig and CD28-Ig bias the downstream response in opposite directions, the latter promoting immunity, and CTLA-4-Ig tolerance, in dendritic cells (DCs) with opposite but flexible programs of antigen presentation. Nevertheless, in the absence of suppressor of cytokine signaling 3 (SOCS3), CD28-Ig-and the associated, dominant ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| IDO1 SOCS3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID