BLNK
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BTK
Gene Ontology Biological Process
- B cell receptor signaling pathway [IBA]
- I-kappaB kinase/NF-kappaB signaling [IMP]
- adaptive immune response [IBA]
- cell maturation [IMP]
- cellular response to molecule of fungal origin [ISO]
- cellular response to reactive oxygen species [ISO]
- histamine secretion by mast cell [ISO]
- innate immune response [IBA]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [IDA]
- regulation of cell proliferation [IBA]
- response to organic substance [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Identification and characterization of a novel BASH N terminus-associated protein, BNAS2.
A B cell-specific adaptor protein, BASH (also known as BLNK or SLP-65), is crucial for B cell receptor (BCR) signaling. BASH binds to various signaling intermediates, such as Btk, PLCgamma2, Vav, and Grb2, through its well defined motifs. Although functional significance of such interactions has been documented, BASH-mediated signal transduction mechanism is not fully understood. Using the yeast two-hybrid system, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID