BCL3
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator [ISO]
- I-kappaB kinase/NF-kappaB signaling [ISO]
- T-helper 1 type immune response [IMP]
- T-helper 2 cell differentiation [IMP]
- antimicrobial humoral response [IMP]
- cellular response to DNA damage stimulus [ISO]
- defense response to bacterium [IMP]
- defense response to protozoan [IMP]
- extracellular matrix organization [IMP]
- follicular dendritic cell differentiation [IMP]
- germinal center formation [IMP]
- humoral immune response mediated by circulating immunoglobulin [IMP]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [ISO]
- marginal zone B cell differentiation [IMP]
- negative regulation of apoptotic process [IGI, IMP, ISO]
- negative regulation of interleukin-8 biosynthetic process [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- negative regulation of tumor necrosis factor biosynthetic process [IMP]
- positive regulation of interferon-gamma production [IMP]
- positive regulation of interleukin-10 biosynthetic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of translation [ISO]
- protein import into nucleus, translocation [ISO]
- regulation of apoptotic process [ISO]
- response to UV-C [ISO]
- response to virus [ISO]
- spleen development [IMP]
- transcription, DNA-templated [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CYLD
Gene Ontology Biological Process
- necroptotic process [IGI]
- negative regulation of NF-kappaB import into nucleus [ISO]
- negative regulation of NF-kappaB transcription factor activity [IBA, ISO]
- negative regulation of T cell differentiation [IDA]
- negative regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [IBA, ISO]
- protein K63-linked deubiquitination [IBA, ISO]
- protein deubiquitination [IMP]
- proteolysis [IBA]
- regulation of intrinsic apoptotic signaling pathway [IBA, ISO]
- regulation of microtubule cytoskeleton organization [ISO]
- regulation of mitotic cell cycle [IBA, ISO]
- ripoptosome assembly involved in necroptotic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling.
Mutations in the CYLD gene cause tumors of hair-follicle keratinocytes. The CYLD gene encodes a deubiquitinase that removes lysine 63-linked ubiquitin chains from TRAF2 and inhibits p65/p50 NF-kappaB activation. Here we show that mice lacking Cyld are highly susceptible to chemically induced skin tumors. Cyld-/- tumors and keratinocytes treated with 12-O-tetradecanoylphorbol-13 acetate (TPA) or UV light are hyperproliferative and have ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID