MITF
Gene Ontology Biological Process
- Wnt signaling pathway [IDA]
- bone remodeling [IMP]
- camera-type eye development [IGI]
- canonical Wnt signaling pathway involved in negative regulation of apoptotic process [IDA]
- cell differentiation [IMP]
- cell fate commitment [IMP]
- melanocyte differentiation [IGI, IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- osteoclast differentiation [IMP]
- pigmentation [IGI, IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO, ISS]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- protein complex assembly [ISO]
- regulation of cell proliferation [IDA]
- regulation of gene expression [IMP]
- regulation of osteoclast differentiation [IGI, IMP]
- regulation of transcription, DNA-templated [IDA]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- chromatin binding [IDA]
- sequence-specific DNA binding [ISA]
- sequence-specific DNA binding transcription factor activity [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, ISO]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- chromatin binding [IDA]
- sequence-specific DNA binding [ISA]
- sequence-specific DNA binding transcription factor activity [IDA]
Gene Ontology Cellular Component
- nucleus [IC, IDA]
- protein complex [ISO]
PSMD14
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The 19S proteasomal lid subunit POH1 enhances the transcriptional activation by Mitf in osteoclasts.
The microphthalmia-associated transcription factor (Mitf) regulates gene expression required for osteoclast differentiation. Genes regulated by Mitf have been previously identified. However, proteins that interact and regulate Mitf's activity in osteoclasts are not well known. Here, we report that POH1, a subunit of the 19S proteasome lid is a regulator of Mitf. We show that POH1 and Mitf interact in osteoclasts ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID