BAIT
GRM8
Glur8, Gprc1h, Mglur8, mGluR8b, mGlur
glutamate receptor, metabotropic 8
GO Process (9)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway [IBA, ISO, ISS, TAS]
- detection of mechanical stimulus involved in sensory perception of pain [IDA]
- negative regulation of cAMP biosynthetic process [ISO]
- regulation of neuron death [TAS]
- regulation of neurotransmitter secretion [IDA]
- regulation of synaptic transmission, glutamatergic [IBA]
- sensory perception of pain [TAS]
- synaptic transmission [IDA, NAS]
- synaptic transmission, glutamatergic [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
ROCK2
ROCK-II, ROK
Rho-associated coiled-coil containing protein kinase 2
GO Process (12)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- Rho protein signal transduction [IMP]
- actin cytoskeleton organization [ISO]
- centrosome duplication [ISO]
- chromosome condensation [TAS]
- dendrite morphogenesis [ISO]
- extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- negative regulation of angiogenesis [ISO]
- neural tube closure [ISO]
- positive regulation of centrosome duplication [ISO]
- protein phosphorylation [ISO]
- regulation of circadian rhythm [ISO, ISS]
- regulation of keratinocyte differentiation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
RanBPM is expressed in synaptic layers of the mammalian retina and binds to metabotropic glutamate receptors.
In the central nervous system, synaptic signal transduction depends on the regulation of neurotransmitter receptors by interacting proteins. Here, we searched for proteins interacting with two metabotropic glutamate receptor type 8 isoforms (mGlu8a and mGlu8b) and identified RanBPM. RanBPM is expressed in several brain regions, including the retina. There, RanBPM is restricted to the inner plexiform layer where it co-localizes ... [more]
FEBS Lett. Jul. 09, 2008; 582(16);2453-7 [Pubmed: 18555800]
Throughput
- High Throughput
Curated By
- BioGRID