BAIT
GRM8
Glur8, Gprc1h, Mglur8, mGluR8b, mGlur
glutamate receptor, metabotropic 8
GO Process (9)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway [IBA, ISO, ISS, TAS]
- detection of mechanical stimulus involved in sensory perception of pain [IDA]
- negative regulation of cAMP biosynthetic process [ISO]
- regulation of neuron death [TAS]
- regulation of neurotransmitter secretion [IDA]
- regulation of synaptic transmission, glutamatergic [IBA]
- sensory perception of pain [TAS]
- synaptic transmission [IDA, NAS]
- synaptic transmission, glutamatergic [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
UBE2I
UbcE2A
ubiquitin-conjugating enzyme E2I
GO Process (10)
GO Function (12)
GO Component (8)
Gene Ontology Biological Process
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of intracellular steroid hormone receptor signaling pathway [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- protein sumoylation [IDA, ISO]
- protein ubiquitination [IDA]
- regulation of receptor activity [IDA]
- ubiquitin-dependent protein catabolic process [TAS]
Gene Ontology Molecular Function- HLH domain binding [ISO]
- RING-like zinc finger domain binding [ISO]
- SUMO transferase activity [IDA, ISO]
- bHLH transcription factor binding [IPI]
- enzyme binding [ISO]
- poly(A) RNA binding [ISO]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- transcription factor binding [ISO]
- ubiquitin protein ligase activity [IBA]
- ubiquitin protein ligase binding [IBA]
- ubiquitin-protein transferase activity [IDA]
- HLH domain binding [ISO]
- RING-like zinc finger domain binding [ISO]
- SUMO transferase activity [IDA, ISO]
- bHLH transcription factor binding [IPI]
- enzyme binding [ISO]
- poly(A) RNA binding [ISO]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- transcription factor binding [ISO]
- ubiquitin protein ligase activity [IBA]
- ubiquitin protein ligase binding [IBA]
- ubiquitin-protein transferase activity [IDA]
Rattus norvegicus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
RanBPM is expressed in synaptic layers of the mammalian retina and binds to metabotropic glutamate receptors.
In the central nervous system, synaptic signal transduction depends on the regulation of neurotransmitter receptors by interacting proteins. Here, we searched for proteins interacting with two metabotropic glutamate receptor type 8 isoforms (mGlu8a and mGlu8b) and identified RanBPM. RanBPM is expressed in several brain regions, including the retina. There, RanBPM is restricted to the inner plexiform layer where it co-localizes ... [more]
FEBS Lett. Jul. 09, 2008; 582(16);2453-7 [Pubmed: 18555800]
Throughput
- High Throughput
Curated By
- BioGRID