GRM4
Gene Ontology Biological Process
- activation of MAPK activity [ISO]
- adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway [IBA, ISO, ISS]
- gamma-aminobutyric acid secretion [TAS]
- learning [ISO]
- negative regulation of apoptotic process [TAS]
- negative regulation of cell proliferation [TAS]
- negative regulation of synaptic transmission [TAS]
- neuron projection development [TAS]
- positive regulation of MAPK cascade [ISO]
- regulation of neuron apoptotic process [NAS]
- regulation of synaptic transmission, glutamatergic [IBA]
- synaptic transmission [ISO]
- synaptic transmission, GABAergic [TAS]
- synaptic transmission, glutamatergic [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PIAS1
Gene Ontology Biological Process
- JAK-STAT cascade [ISA]
- mitotic S phase [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of nucleic acid-templated transcription [ISA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of protein sumoylation [ISO]
- positive regulation of smooth muscle cell differentiation [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein sumoylation [IDA]
- protein-DNA complex assembly [ISO]
- regulation of cell proliferation [IMP]
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
SUMO E3 ligases are expressed in the retina and regulate SUMOylation of the metabotropic glutamate receptor 8b.
The central nervous system regulates neuronal excitability by macromolecular signalling complexes that consist of functionally related proteins, including neurotransmitter receptors, enzymes and scaffolds. The composition of these signal complexes is regulated by post-translational modifications, such as phosphorylation and SUMOylation (SUMO is small ubiquitin-related modifier). In the present study, we searched for proteins interacting with the intracellular C-termini of the metabotropic ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID