GRM7
Gene Ontology Biological Process
- adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway [IDA, ISO]
- adult behavior [ISO]
- associative learning [ISO]
- behavioral fear response [ISO]
- calcium ion transmembrane transport [ISO]
- conditioned taste aversion [ISO]
- learning or memory [TAS]
- memory [ISO]
- multicellular organismal response to stress [ISO]
- negative regulation of adenylate cyclase activity [ISO]
- negative regulation of cAMP biosynthetic process [ISO]
- negative regulation of glutamate secretion [IDA]
- neurological system process [ISO]
- regulation of cyclase activity [ISO]
- regulation of ion transmembrane transport [ISO]
- regulation of synaptic transmission, glutamatergic [IBA]
- sensory perception of sound [ISO]
- short-term memory [ISO]
- synaptic transmission [ISO]
- transmission of nerve impulse [ISO]
Gene Ontology Molecular Function- PDZ domain binding [IPI]
- adenylate cyclase inhibiting G-protein coupled glutamate receptor activity [IDA]
- adenylate cyclase inhibitor activity [ISO]
- calcium channel regulator activity [IBA, ISO]
- calcium ion binding [ISO]
- calcium-dependent protein binding [IPI]
- calmodulin binding [IPI]
- glutamate binding [IDA, ISO]
- glutamate receptor activity [ISO]
- group III metabotropic glutamate receptor activity [IDA, ISO, TAS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- serine binding [ISO]
- voltage-gated calcium channel activity [ISO]
- PDZ domain binding [IPI]
- adenylate cyclase inhibiting G-protein coupled glutamate receptor activity [IDA]
- adenylate cyclase inhibitor activity [ISO]
- calcium channel regulator activity [IBA, ISO]
- calcium ion binding [ISO]
- calcium-dependent protein binding [IPI]
- calmodulin binding [IPI]
- glutamate binding [IDA, ISO]
- glutamate receptor activity [ISO]
- group III metabotropic glutamate receptor activity [IDA, ISO, TAS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- serine binding [ISO]
- voltage-gated calcium channel activity [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- asymmetric synapse [IDA]
- axon [IDA]
- axon terminus [IDA]
- cell cortex [ISO]
- cell surface [IDA]
- dendrite [IDA, ISO]
- dendritic shaft [IDA]
- integral component of membrane [ISO]
- integral component of plasma membrane [IBA]
- membrane [IDA]
- neuronal cell body [IDA]
- postsynaptic membrane [IDA]
- presynaptic active zone [IDA]
- presynaptic membrane [IDA, ISO]
- protein complex [IDA]
- receptor complex [ISO]
- rough endoplasmic reticulum [IDA]
- synapse [IDA]
- terminal bouton [IDA]
PIAS3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
SUMO E3 ligases are expressed in the retina and regulate SUMOylation of the metabotropic glutamate receptor 8b.
The central nervous system regulates neuronal excitability by macromolecular signalling complexes that consist of functionally related proteins, including neurotransmitter receptors, enzymes and scaffolds. The composition of these signal complexes is regulated by post-translational modifications, such as phosphorylation and SUMOylation (SUMO is small ubiquitin-related modifier). In the present study, we searched for proteins interacting with the intracellular C-termini of the metabotropic ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID