BAIT
KCNB1
DRK1PC, Kcr1-1, Kv2.1, Shab
potassium voltage gated channel, Shab-related subfamily, member 1
GO Process (3)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
SUMO3
small ubiquitin-like modifier 3
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
SUMO modification of cell surface Kv2.1 potassium channels regulates the activity of rat hippocampal neurons.
Voltage-gated Kv2.1 potassium channels are important in the brain for determining activity-dependent excitability. Small ubiquitin-like modifier proteins (SUMOs) regulate function through reversible, enzyme-mediated conjugation to target lysine(s). Here, sumoylation of Kv2.1 in hippocampal neurons is shown to regulate firing by shifting the half-maximal activation voltage (V(1/2)) of channels up to 35 mV. Native SUMO and Kv2.1 are shown to interact ... [more]
J. Gen. Physiol. May. 01, 2011; 137(5);441-54 [Pubmed: 21518833]
Throughput
- Low Throughput
Curated By
- BioGRID