BAIT
KCNB1
DRK1PC, Kcr1-1, Kv2.1, Shab
potassium voltage gated channel, Shab-related subfamily, member 1
GO Process (3)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
SUMO1
small ubiquitin-like modifier 1
GO Process (14)
GO Function (5)
GO Component (10)
Gene Ontology Biological Process
- PML body organization [ISO]
- negative regulation of DNA binding [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- palate development [ISO, ISS]
- positive regulation of calcium-transporting ATPase activity [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein complex assembly [ISO]
- protein localization to nuclear pore [ISO]
- protein sumoylation [ISO, ISS]
- regulation of calcium ion transmembrane transport [ISO]
- regulation of cardiac muscle cell contraction [ISO]
- regulation of protein stability [ISO]
- regulation of transcription, DNA-templated [ISO]
Gene Ontology Molecular Function
Rattus norvegicus
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
SUMO modification of cell surface Kv2.1 potassium channels regulates the activity of rat hippocampal neurons.
Voltage-gated Kv2.1 potassium channels are important in the brain for determining activity-dependent excitability. Small ubiquitin-like modifier proteins (SUMOs) regulate function through reversible, enzyme-mediated conjugation to target lysine(s). Here, sumoylation of Kv2.1 in hippocampal neurons is shown to regulate firing by shifting the half-maximal activation voltage (V(1/2)) of channels up to 35 mV. Native SUMO and Kv2.1 are shown to interact ... [more]
J. Gen. Physiol. May. 01, 2011; 137(5);441-54 [Pubmed: 21518833]
Throughput
- Low Throughput
Curated By
- BioGRID