BAIT

SVIP

small VCP/p97-interacting protein

GO Process (4)

GO Function (1)

GO Component (3)

Gene Ontology Biological Process

negative regulation of ER-associated ubiquitin-dependent protein catabolic process [IMP]

negative regulation of protein complex assembly [IMP]

positive regulation of autophagy [IMP]

positive regulation of protein lipidation [IMP]

Gene Ontology Molecular Function

protein self-association [IMP]

Gene Ontology Cellular Component

Hrd1p ubiquitin ligase complex [IDA]

endoplasmic reticulum membrane [IDA]

extracellular vesicular exosome [IDA]

CRISPR Database HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB

Homo sapiens

PREY

LAMP1

CD107a, LAMPA, LGP120

lysosomal-associated membrane protein 1

Human Papilloma Virus (HPV) Project

GO Process (7)

GO Function (2)

GO Component (7)

Gene Ontology Biological Process

Golgi to lysosome transport [IMP]

establishment of protein localization to organelle [IMP]

granzyme-mediated apoptotic signaling pathway [IMP]

positive regulation of natural killer cell degranulation [IMP]

positive regulation of natural killer cell mediated cytotoxicity [IMP]

protein stabilization [ISS]

regulation of organelle transport along microtubule [IMP]

Gene Ontology Molecular Function

enzyme binding [IPI]
protein binding [IPI]

Gene Ontology Cellular Component

cytoplasm [IDA]

extracellular vesicular exosome [IDA]

integral component of plasma membrane [TAS]

late endosome [IDA]

plasma membrane [IDA]

CRISPR Database OMIM VEGA HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Co-localization

Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

SVIP induces localization of p97/VCP to the plasma and lysosomal membranes and regulates autophagy.

Wang Y, Ballar P, Zhong Y, Zhang X, Liu C, Zhang YJ, Monteiro MJ, Li J, Fang S

The small p97/VCP-interacting protein (SVIP) functions as an inhibitor of the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway. Here we show that overexpression of SVIP in HeLa cells leads to localization of p97/VCP at the plasma membrane, intracellular foci and juxtanuclear vacuoles. The p97/VCP-positive vacuolar structures colocalized or associated with LC3 and lamp1, suggesting that SVIP may regulate autophagy. In support ... [more]

PLoS ONE Sep. 13, 2011; 6(8);e24478 [Pubmed: 21909394]

Throughput

Low Throughput

Curated By

BioGRID