BAIT

FBXW8

FBW6, FBW8, FBX29, FBXO29, FBXW6
F-box and WD repeat domain containing 8
UPS Project
Homo sapiens
PREY

CCT6B

CCT-zeta-2, CCTZ-2, Cctz2, TCP-1-zeta-2, TSA303
chaperonin containing TCP1, subunit 6B (zeta 2)
GO Process (3)
GO Function (1)
GO Component (0)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning.

Litterman N, Ikeuchi Y, Gallardo G, O'Connell BC, Sowa ME, Gygi SP, Harper JW, Bonni A

The elaboration of dendrites in neurons requires secretory trafficking through the Golgi apparatus, but the mechanisms that govern Golgi function in neuronal morphogenesis in the brain have remained largely unexplored. Here, we report that the E3 ubiquitin ligase Cul7(Fbxw8) localizes to the Golgi complex in mammalian brain neurons. Inhibition of Cul7(Fbxw8) by independent approaches including Fbxw8 knockdown reveals that Cul7(Fbxw8) ... [more]

PLoS Biol. May. 01, 2011; 9(5);e1001060 [Pubmed: 21572988]

Throughput

  • Low Throughput

Curated By

  • BioGRID