BAIT
PIDD1
LRDD, PIDD
p53-induced death domain protein 1
GO Process (6)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [IMP]
- cellular response to DNA damage stimulus [IDA]
- negative regulation of apoptotic process [IMP]
- positive regulation of NF-kappaB transcription factor activity [TAS]
- positive regulation of apoptotic process [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
AIFM1
AIF, CMT2D, CMTX4, COWCK, COXPD6, NADMR, NAMSD, PDCD8, RP3-438D16.2
apoptosis-inducing factor, mitochondrion-associated, 1
GO Process (9)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- DNA catabolic process [TAS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- apoptotic DNA fragmentation [TAS]
- apoptotic process [IMP]
- chromosome condensation [TAS]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISS]
- mitochondrial respiratory chain complex I assembly [IMP]
- neuron differentiation [IDA]
- positive regulation of apoptotic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
PIDD orchestrates translesion DNA synthesis in response to UV irradiation.
PIDD has been implicated in survival and apoptotic pathways in response to DNA damage, and a role for PIDD was recently identified in non-homologous end-joining (NHEJ) repair induced by γ-irradiation. Here, we present an interaction of PIDD with PCNA, first identified in a proteomics screen. PCNA has essential functions in DNA replication and repair following UV irradiation. Translesion synthesis (TLS) ... [more]
Cell Death Differ. Jun. 01, 2011; 18(6);1036-45 [Pubmed: 21415862]
Throughput
- High Throughput
Curated By
- BioGRID