TRIAP1
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator [IDA]
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [TAS]
- cellular response to UV [IDA]
- negative regulation of apoptotic process [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP]
- negative regulation of release of cytochrome c from mitochondria [IMP]
- phospholipid transport [IDA]
- positive regulation of phospholipid transport [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of membrane lipid distribution [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
APAF1
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [IDA, TAS]
- apoptotic process [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- nervous system development [TAS]
- positive regulation of apoptotic process [TAS]
- regulation of apoptotic process [TAS]
- response to G1 DNA damage checkpoint signaling [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway.
Although a number of p53 target genes have been identified, the mechanisms of p53-dependent activities that determine cellular survival or death are still not fully understood. Here we report isolation of a novel p53 target gene, designated p53-inducible cell-survival factor (p53CSV). p53CSV contains a p53-binding site within its second exon and the reduction of expression by small interfering RNA enhanced ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID