IKBKG
Gene Ontology Biological Process
- B cell homeostasis [ISO]
- NF-kappaB import into nucleus [TAS]
- activation of NF-kappaB-inducing kinase activity [ISO]
- cellular response to DNA damage stimulus [ISO]
- establishment of vesicle localization [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IBA, ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO, TAS]
- positive regulation of transcription from RNA polymerase II promoter [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SUMO1
Gene Ontology Biological Process
- PML body organization [ISO]
- negative regulation of DNA binding [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- palate development [ISO, ISS]
- positive regulation of calcium-transporting ATPase activity [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein complex assembly [ISO]
- protein localization to nuclear pore [ISO]
- protein sumoylation [ISO, ISS]
- regulation of calcium ion transmembrane transport [ISO]
- regulation of cardiac muscle cell contraction [ISO]
- regulation of protein stability [ISO]
- regulation of transcription, DNA-templated [ISO]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
SYT-SSX1 (synovial sarcoma translocated) regulates PIASy ligase activity to cause overexpression of NCOA3 protein.
Chromosomal translocations are a major source of genetic abnormalities causally linked to certain malignancies. Synovial sarcoma is an aggressive soft tissue tumor characterized by a chromosomal translocation between chromosome 18 and X, generating oncoproteins such as SYT-SSX1 and SYT-SSX2. The molecular mechanism underlying the oncogenic potential of SYT-SSX1/2 is not clear. Here we show that SYT-SSX1 leads to up-regulation of ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID