BAIT

NEDD4

NEDD4-1, RPF1, PIG53
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
GO Process (26)
GO Function (10)
GO Component (11)
Homo sapiens
PREY

CDK5R1

CDK5P35, CDK5R, NCK5A, p23, p25, p35, p35nck5a
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays.

Persaud A, Alberts P, Amsen EM, Xiong X, Wasmuth J, Saadon Z, Fladd C, Parkinson J, Rotin D

Target recognition by the ubiquitin system is mediated by E3 ubiquitin ligases. Nedd4 family members are E3 ligases comprised of a C2 domain, 2-4 WW domains that bind PY motifs (L/PPxY) and a ubiquitin ligase HECT domain. The nine Nedd4 family proteins in mammals include two close relatives: Nedd4 (Nedd4-1) and Nedd4L (Nedd4-2), but their global substrate recognition or differences ... [more]

Mol. Syst. Biol. Dec. 03, 2009; 5(0);333 [Pubmed: 19953087]

Throughput

  • High Throughput

Additional Notes

  • High Throughput: Protein microarray

Curated By

  • BioGRID