UBC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HMOX1
Gene Ontology Biological Process
- angiogenesis [IDA]
- cell death [IDA]
- cellular response to arsenic-containing substance [ISO]
- cellular response to cadmium ion [ISO]
- cellular response to hypoxia [ISO]
- cellular response to nutrient [IEP]
- erythrocyte homeostasis [ISO]
- heme catabolic process [IDA, ISO]
- heme metabolic process [ISO]
- heme oxidation [ISO, TAS]
- intracellular signal transduction [IDA]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA]
- iron ion homeostasis [ISO]
- negative regulation of DNA binding [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- negative regulation of mast cell cytokine production [IDA]
- negative regulation of mast cell degranulation [IDA]
- negative regulation of muscle cell apoptotic process [IDA]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of smooth muscle cell proliferation [IMP, ISO]
- phospholipid metabolic process [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of angiogenesis [IMP]
- positive regulation of smooth muscle cell proliferation [ISO]
- protein homooligomerization [ISO]
- regulation of blood pressure [IDA]
- regulation of sequence-specific DNA binding transcription factor activity [IDA]
- regulation of transcription from RNA polymerase II promoter in response to iron [ISO]
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IDA]
- response to estrogen [IDA]
- response to hydrogen peroxide [IDA]
- response to hypoxia [IEP]
- response to nicotine [ISO]
- response to oxidative stress [IDA, ISO]
- small GTPase mediated signal transduction [IDA]
- wound healing involved in inflammatory response [ISO]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Melatonin synergistically increases resveratrol-induced heme oxygenase-1 expression through the inhibition of ubiquitin-dependent proteasome pathway: a possible role in neuroprotection.
Melatonin is an indoleamine secreted by the pineal gland as well as a plant-derived product, and resveratrol (RSV) is a naturally occurring polyphenol synthesized by a variety of plant species; both molecules act as a neuroprotector and antioxidant. Recent studies have demonstrated that RSV reduced the incidence of Alzheimer's disease and stroke, while melatonin supplementation was found to reduce the ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HMOX1 UBC | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID