BAIT
SFN
YWHAS
stratifin
GO Process (13)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- apoptotic process [TAS]
- establishment of skin barrier [ISS]
- intrinsic apoptotic signaling pathway [TAS]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA]
- membrane organization [TAS]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of protein kinase activity [TAS]
- negative regulation of protein serine/threonine kinase activity [TAS]
- positive regulation of epidermal cell differentiation [ISS]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- regulation of epidermal cell division [ISS]
- release of cytochrome c from mitochondria [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
EXO1
HEX1, hExoI, RP11-553N16.2
exonuclease 1
GO Process (7)
GO Function (9)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function- 5'-3' exodeoxyribonuclease activity [IDA]
- 5'-3' exonuclease activity [ISS]
- DNA binding [IDA]
- RNA-DNA hybrid ribonuclease activity [TAS]
- double-stranded DNA 5'-3' exodeoxyribonuclease activity [IDA]
- exonuclease activity [TAS]
- flap endonuclease activity [IDA]
- protein binding [IPI]
- single-stranded DNA 5'-3' exodeoxyribonuclease activity [IDA]
- 5'-3' exodeoxyribonuclease activity [IDA]
- 5'-3' exonuclease activity [ISS]
- DNA binding [IDA]
- RNA-DNA hybrid ribonuclease activity [TAS]
- double-stranded DNA 5'-3' exodeoxyribonuclease activity [IDA]
- exonuclease activity [TAS]
- flap endonuclease activity [IDA]
- protein binding [IPI]
- single-stranded DNA 5'-3' exodeoxyribonuclease activity [IDA]
Gene Ontology Cellular Component
- nucleoplasm [IDA]
- nucleus [IDA]
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif.
Human exonuclease 1 (hEXO1) acts directly in diverse DNA processing events, including replication, mismatch repair (MMR), and double strand break repair (DSBR), and it was also recently described to function as damage sensor and apoptosis inducer following DNA damage. In contrast, 14-3-3 proteins are regulatory phosphorserine/threonine binding proteins involved in the control of diverse cellular events, including cell cycle checkpoint ... [more]
Unknown Jan. 03, 2012; 0(0); [Pubmed: 22222486]
Throughput
- Low Throughput
Related interactions
Curated By
- BioGRID